CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007651
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Aquaporin PIP2-2 
Protein Synonyms/Alias
 Plasma membrane intrinsic protein 2-2; AtPIP2;2; Plasma membrane intrinsic protein 2b; PIP2b; TMP2b 
Gene Name
 PIP2-2 
Gene Synonyms/Alias
 PIP2B; At2g37170; T2N18.7 
Created Date
 July 27, 2013 
Organism
 Arabidopsis thaliana (Mouse-ear cress) 
NCBI Taxa ID
 3702 
Lysine Modification
Position
Peptide
Type
References
3*****MAKDVEGPEGmethylation[1]
Reference
 [1] Update on activities at the Universal Protein Resource (UniProt) in 2013.
 e="String">UniProt Consortium.
 Nucleic Acids Res. 2013 Jan;41(Database issue):D43-7. [PMID: 23161681
Functional Description
 Water channel required to facilitate the transport of water across cell membrane. Plays an predominant role in root water uptake process in conditions of reduced transpiration, and in osmotic fluid transport. Its function is impaired by Hg(2+). Inhibited by cytosolic acidosis which occurs during anoxia in roots. 
Sequence Annotation
 MOTIF 105 107 NPA 1.
 MOTIF 226 228 NPA 2.
 MOD_RES 3 3 N6,N6-dimethyllysine; partial.
 MOD_RES 278 278 Phosphoserine.
 MOD_RES 281 281 Phosphoserine.  
Keyword
 Cell membrane; Complete proteome; Membrane; Methylation; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 285 AA 
Protein Sequence
MAKDVEGPEG FQTRDYEDPP PTPFFDADEL TKWSLYRAVI AEFVATLLFL YITVLTVIGY 60
KIQSDTKAGG VDCGGVGILG IAWAFGGMIF ILVYCTAGIS GGHINPAVTF GLFLARKVSL 120
IRAVLYMVAQ CLGAICGVGF VKAFQSSYYD RYGGGANSLA DGYNTGTGLA AEIIGTFVLV 180
YTVFSATDPK RNARDSHVPV LAPLPIGFAV FMVHLATIPI TGTGINPARS FGAAVIYNKS 240
KPWDDHWIFW VGPFIGAAIA AFYHQFVLRA SGSKSLGSFR SAANV 285 
Gene Ontology
 GO:0009507; C:chloroplast; IDA:TAIR.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:TAIR.
 GO:0009506; C:plasmodesma; IDA:TAIR.
 GO:0015250; F:water channel activity; IDA:TAIR.
 GO:0009737; P:response to abscisic acid stimulus; IDA:TAIR.
 GO:0009414; P:response to water deprivation; IEP:TAIR. 
Interpro
 IPR023271; Aquaporin-like.
 IPR000425; MIP.
 IPR022357; MIP_CS. 
Pfam
 PF00230; MIP 
SMART
  
PROSITE
 PS00221; MIP 
PRINTS
 PR00783; MINTRINSICP.