UniProt Accession

 ATPA_RAT; P15999; Q6P753 

Genbank Protein ID

 BC061830; J05266; X56133 

Genbank Nucleotide ID

 AAH61830.1; AAA40784.1; CAA39599.1 

Protein Name

 ATP synthase subunit alpha, mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 Atp5a1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
541	EQSDAKLKEIVTNFL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites (By similarity). 

Sequence Annotation

 NP_BIND 212 219 ATP (By similarity).
 MOD_RES 44 44 Pyrrolidone carboxylic acid (By
 MOD_RES 76 76 Phosphoserine (By similarity).
 MOD_RES 132 132 N6-acetyllysine (By similarity).
 MOD_RES 161 161 N6-acetyllysine (By similarity).
 MOD_RES 166 166 Phosphoserine (By similarity).
 MOD_RES 230 230 N6-acetyllysine (By similarity).
 MOD_RES 239 239 N6-acetyllysine (By similarity).
 MOD_RES 261 261 N6-acetyllysine (By similarity).
 MOD_RES 305 305 N6-acetyllysine (By similarity).
 MOD_RES 427 427 N6-acetyllysine (By similarity).
 MOD_RES 434 434 N6-acetyllysine (By similarity).
 MOD_RES 498 498 N6-acetyllysine (By similarity).
 MOD_RES 506 506 N6-acetyllysine (By similarity).
 MOD_RES 531 531 N6-acetyllysine (By similarity).
 MOD_RES 539 539 N6-acetyllysine (By similarity).  

Keyword

 3D-structure; Acetylation; ATP synthesis; ATP-binding; Cell membrane; CF(1); Complete proteome; Direct protein sequencing; Hydrogen ion transport; Ion transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Nucleotide-binding; Phosphoprotein; Pyrrolidone carboxylic acid; Reference proteome; Transit peptide; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 553 AA 

Protein Sequence

Gene Ontology

 GO:0000275; C:mitochondrial proton-transporting ATP synthase complex, catalytic core F(1); IDA:RGD.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0043531; F:ADP binding; IDA:RGD.
 GO:0005524; F:ATP binding; IDA:RGD.
 GO:0016887; F:ATPase activity; IMP:RGD.
 GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:InterPro.
 GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
 GO:0006172; P:ADP biosynthetic process; IDA:RGD.
 GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
 GO:0015986; P:ATP synthesis coupled proton transport; IEA:InterPro. 

Interpro

 IPR020003; ATPase_a/bsu_AS.
 IPR004100; ATPase_a/bsu_N.
 IPR005294; ATPase_F1-cplx_asu.
 IPR023366; ATPase_F1/A1-cplx_a_su_N.
 IPR000793; ATPase_F1/V1/A1-cplx_a/bsu_C.
 IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00006; ATP-synt_ab
 PF00306; ATP-synt_ab_C
 PF02874; ATP-synt_ab_N 

SMART

  

PROSITE

 PS00152; ATPASE_ALPHA_BETA 

PRINTS