CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015816
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Monocarboxylate transporter 9 
Protein Synonyms/Alias
 MCT 9; Solute carrier family 16 member 9 
Gene Name
 SLC16A9 
Gene Synonyms/Alias
 C10orf36; MCT9 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
219SIYNEKGKNLEENINubiquitination[1]
230ENINILDKSYSSEEKubiquitination[1]
248TLANGDWKQDSLLHKubiquitination[1]
504APTTFLYKVASNV**ubiquitination[2, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
 Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity). 
Sequence Annotation
  
Keyword
 Cell membrane; Complete proteome; Membrane; Polymorphism; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 509 AA 
Protein Sequence
MELKKSPDGG WGWVIVFVSF LTQFLCYGSP LAVGVLYIEW LDAFGEGKGK TAWVGSLASG 60
VGLLASPVCS LCVSSFGARP VTIFSGFMVA GGLMLSSFAP NIYFLFFSYG IVVGLGCGLL 120
YTATVTITCQ YFDDRRGLAL GLISTGSSVG LFIYAALQRM LVEFYGLDGC LLIVGALALN 180
ILACGSLMRP LQSSDCPLPK KIAPEDLPDK YSIYNEKGKN LEENINILDK SYSSEEKCRI 240
TLANGDWKQD SLLHKNPTVT HTKEPETYKK KVAEQTYFCK QLAKRKWQLY KNYCGETVAL 300
FKNKVFSALF IAILLFDIGG FPPSLLMEDV ARSSNVKEEE FIMPLISIIG IMTAVGKLLL 360
GILADFKWIN TLYLYVATLI IMGLALCAIP FAKSYVTLAL LSGILGFLTG NWSIFPYVTT 420
KTVGIEKLAH AYGILMFFAG LGNSLGPPIV GWFYDWTQTY DIAFYFSGFC VLLGGFILLL 480
AALPSWDTCN KQLPKPAPTT FLYKVASNV 509 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
 GO:0046415; P:urate metabolic process; IMP:BHF-UCL. 
Interpro
 IPR011701; MFS.
 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt. 
Pfam
 PF07690; MFS_1 
SMART
  
PROSITE
 PS50850; MFS 
PRINTS