CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041149
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase 
Protein Synonyms/Alias
  
Gene Name
 Gne 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
188AGCPSYDKLLSAKNKubiquitination[1]
195KLLSAKNKDYMSIIRubiquitination[1]
210MWLGDDVKCKDYIVAubiquitination[1]
212LGDDVKCKDYIVALQubiquitination[1]
227HPVTTDIKHSIKMFEubiquitination[1]
259PNIDAGSKEMVRVMRubiquitination[1]
342RDADTQDKILQALHLubiquitination[1]
353ALHLQFGKQYPCSKIubiquitination[1]
359GKQYPCSKIYGDGNAubiquitination[1]
375PRILKFLKSIDLQEPubiquitination[1]
385DLQEPLQKKFCFPPVubiquitination[1]
386LQEPLQKKFCFPPVKubiquitination[1]
440KYTQFNPKTYEERISubiquitination[1]
544VEGMSVPKDEAVGALubiquitination[1]
558LHLIQAAKLGNVKAQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 648 AA 
Protein Sequence
MEKNGNNRKL RVCVATCNRA DYSKLAPIMF GIKTEPAFFE LDVVVLGSHL IDDYGNTYRM 60
IEQDDFDINT RLHTIVRGED EAAMVESVGL ALVKLPDVLN RLKPDIMIVH GDRFDALALA 120
TSAALMNIRI LHIEGGEVSG TIDDSIRHAI TKLAHYHVCC TRSAEQHLIS MCEDHDRILL 180
AGCPSYDKLL SAKNKDYMSI IRMWLGDDVK CKDYIVALQH PVTTDIKHSI KMFELTLDAL 240
ISFNKRTLVL FPNIDAGSKE MVRVMRKKGI EHHPNFRAVK HVPFDQFIQL VAHAGCMIGN 300
SSCGVREVGA FGTPVINLGT RQIGRETGEN VLHVRDADTQ DKILQALHLQ FGKQYPCSKI 360
YGDGNAVPRI LKFLKSIDLQ EPLQKKFCFP PVKENISQDI DHILETLSAL AVDLGGTNLR 420
VAIVSMKGEI VKKYTQFNPK TYEERISLIL QMCVEAAAEA VKLNCRILGV GIGGGIIHQH 480
ELIHGSSFCA AELGHLVVSL DGPDCSCGSH GCIEAYASGM ALQREAKKLH DEDLLLVEGM 540
SVPKDEAVGA LHLIQAAKLG NVKAQSILRT AGTALGLGVV NILHTMNPSL VILSGVLASH 600
YIHIVKDVIR QQALSSVQDV DVVVSDLVDP ALLGAASMVL DYTTRRIH 648 
Gene Ontology
 GO:0003824; F:catalytic activity; ISS:MGI.
 GO:0009384; F:N-acylmannosamine kinase activity; IEA:InterPro.
 GO:0008761; F:UDP-N-acetylglucosamine 2-epimerase activity; IEA:InterPro.
 GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
 GO:0046380; P:N-acetylneuraminate biosynthetic process; IEA:InterPro.
 GO:0006054; P:N-acetylneuraminate metabolic process; TAS:MGI.
 GO:0006047; P:UDP-N-acetylglucosamine metabolic process; IEA:InterPro. 
Interpro
 IPR000600; ROK.
 IPR020004; UDP-GlcNAc_Epase.
 IPR003331; UDP_GlcNAc_Epimerase_2. 
Pfam
 PF02350; Epimerase_2
 PF00480; ROK 
SMART
  
PROSITE
 PS01125; ROK 
PRINTS