CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007967
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Insulin-like growth factor-binding protein 2 
Protein Synonyms/Alias
 IBP-2; IGF-binding protein 2; IGFBP-2; mIGFBP-2 
Gene Name
 Igfbp2 
Gene Synonyms/Alias
 Igfbp-2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
167KPLKSGMKELAVFREubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. 
Sequence Annotation
 DOMAIN 36 118 IGFBP N-terminal.
 DOMAIN 204 286 Thyroglobulin type-1.
 MOTIF 281 283 Cell attachment site.
 DISULFID 207 241 By similarity.
 DISULFID 252 263 By similarity.
 DISULFID 265 286 By similarity.  
Keyword
 Complete proteome; Disulfide bond; Glycoprotein; Growth factor binding; Growth regulation; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 305 AA 
Protein Sequence
MLPRLGGPAL PLLLPSLLLL LLLGAGGCGP GVRAEVLFRC PPCTPERLAA CGPPPDAPCA 60
ELVREPGCGC CSVCARQEGE ACGVYIPRCA QTLRCYPNPG SELPLKALVT GAGTCEKRRV 120
GTTPQQVADS DDDHSEGGLV ENHVDGTMNM LGGGSSAGRK PLKSGMKELA VFREKVNEQH 180
RQMGKGAKHL SLEEPKKLRP PPARTPCQQE LDQVLERIST MRLPDDRGPL EHLYSLHIPN 240
CDKHGRYNLK QCKMSLNGQR GECWCVNPNT GKPIQGAPTI RGDPECHLFY NEQQETGGAH 300
AQSVQ 305 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0031410; C:cytoplasmic vesicle; IEA:Compara.
 GO:0005615; C:extracellular space; IDA:MGI.
 GO:0031994; F:insulin-like growth factor I binding; ISS:UniProtKB.
 GO:0031995; F:insulin-like growth factor II binding; ISS:UniProtKB.
 GO:0007568; P:aging; IEA:Compara.
 GO:0032870; P:cellular response to hormone stimulus; IEA:Compara.
 GO:0007565; P:female pregnancy; IEA:Compara.
 GO:0042104; P:positive regulation of activated T cell proliferation; ISS:UniProtKB.
 GO:0001558; P:regulation of cell growth; IEA:InterPro.
 GO:0043567; P:regulation of insulin-like growth factor receptor signaling pathway; ISS:UniProtKB.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0032355; P:response to estradiol stimulus; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0010226; P:response to lithium ion; IEA:Compara.
 GO:0009612; P:response to mechanical stimulus; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0032526; P:response to retinoic acid; IEA:Compara.
 GO:0006950; P:response to stress; IEA:Compara.
 GO:0007165; P:signal transduction; IEA:Compara. 
Interpro
 IPR009030; Growth_fac_rcpt_N_dom.
 IPR012210; IGFBP-2.
 IPR000867; IGFBP-like.
 IPR009168; IGFBP1-6.
 IPR022321; IGFBP_1-6_chordata.
 IPR017891; Insulin_GF-bd_Cys-rich_CS.
 IPR000716; Thyroglobulin_1. 
Pfam
 PF00219; IGFBP
 PF00086; Thyroglobulin_1 
SMART
 SM00121; IB
 SM00211; TY 
PROSITE
 PS00222; IGFBP_N_1
 PS51323; IGFBP_N_2
 PS00484; THYROGLOBULIN_1_1
 PS51162; THYROGLOBULIN_1_2 
PRINTS
 PR01976; IGFBPFAMILY.
 PR01978; IGFBPFAMILY2.