UniProt Accession

 RRAGC_HUMAN; Q9HB90; Q9H202; Q9H8Q8 

Genbank Protein ID

 AF323609; AF272035; AL139260; BC016668; AK023373 

Genbank Nucleotide ID

 AAG45221.1; AAG32662.1; CAI23049.1; AAH16668.1; BAB14548.1 

Protein Name

 Ras-related GTP-binding protein C 

Protein Synonyms/Alias

 Rag C; RagC; GTPase-interacting protein 2; TIB929 

Gene Name

 RRAGC 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
79	SGKSSIQKVVFHKMS	ubiquitination	[1, 2, 3]
329	NTTVLYLKEVTKFLA	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. 

Sequence Annotation

 NP_BIND 68 75 GTP (By similarity).
 NP_BIND 116 120 GTP (By similarity).
 NP_BIND 178 181 GTP (By similarity).
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 2 2 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; GTP-binding; Lysosome; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 399 AA 

Protein Sequence

Gene Ontology

 GO:0005764; C:lysosome; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0019003; F:GDP binding; IDA:UniProtKB.
 GO:0005525; F:GTP binding; IDA:HGNC.
 GO:0003924; F:GTPase activity; IDA:UniProtKB.
 GO:0000287; F:magnesium ion binding; NAS:UniProtKB.
 GO:0006915; P:apoptotic process; NAS:UniProtKB.
 GO:0016049; P:cell growth; NAS:UniProtKB.
 GO:0034613; P:cellular protein localization; ISS:UniProtKB.
 GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
 GO:0008380; P:RNA splicing; NAS:UniProtKB.
 GO:0007264; P:small GTPase mediated signal transduction; TAS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; NAS:UniProtKB. 

Interpro

 IPR006762; Gtr1_RagA.
 IPR027417; P-loop_NTPase. 

Pfam

 PF04670; Gtr1_RagA 

SMART

  

PROSITE

  

PRINTS