UniProt Accession

 IFRD1_HUMAN; O00458; B7Z5G1; O75234; Q5U013; Q9BVE4 

Genbank Protein ID

 Y10313; AK298894; AK315967; BT019889; BT019890; AC002459; AC005192; AC079741; BC001272 

Genbank Nucleotide ID

 CAA71366.1; BAH12897.1; BAH14338.1; AAV38692.1; AAV38693.1; AAC24562.1; AAH01272.1 

Protein Name

 Interferon-related developmental regulator 1 

Protein Synonyms/Alias

 Nerve growth factor-inducible protein PC4 

Gene Name

 IFRD1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
174	KTLGPILKKIICDGS	ubiquitination	[1]
175	TLGPILKKIICDGSA	ubiquitination	[1, 2]
416	AATLKTMKISRFERH	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (By similarity). 

Sequence Annotation

  

Keyword

 Alternative splicing; Complete proteome; Developmental protein; Differentiation; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 451 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:Compara.
 GO:0007527; P:adult somatic muscle development; IEA:Compara.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0007518; P:myoblast fate determination; TAS:ProtInc. 

Interpro

 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR006921; Interferon-rel_develop_reg_C.
 IPR007701; Interferon-rel_develop_reg_N. 

Pfam

 PF05004; IFRD
 PF04836; IFRD_C 

SMART

  

PROSITE

  

PRINTS