CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020018
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Coatomer subunit alpha-1 
Protein Synonyms/Alias
 Alpha-coat protein 1; Alpha-COP 1 
Gene Name
 Os03g0711400, LOC_Os03g50340; OsJ_011822, OSJNBb0033N16.10 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Oryza sativa subsp. japonica (Rice) 
NCBI Taxa ID
 39947 
Lysine Modification
Position
Peptide
Type
References
270IVSNSEDKSIRIWDAubiquitination[1]
Reference
 [1] Proteomic analysis of salt-responsive ubiquitin-related proteins in rice roots.
 Liu CW, Hsu YK, Cheng YH, Yen HC, Wu YP, Wang CS, Lai CC.
 Rapid Commun Mass Spectrom. 2012 Aug 15;26(15):1649-60. [PMID: 22730086
Functional Description
 The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). 
Sequence Annotation
 REPEAT 7 48 WD 1.
 REPEAT 49 88 WD 2.
 REPEAT 91 132 WD 3.
 REPEAT 133 172 WD 4.
 REPEAT 202 241 WD 5.
 REPEAT 246 285 WD 6.
 REPEAT 288 326 WD 7.
 REPEAT 363 404 WD 8.
 REPEAT 450 489 WD 9.  
Keyword
 Complete proteome; Cytoplasm; Cytoplasmic vesicle; ER-Golgi transport; Golgi apparatus; Membrane; Protein transport; Reference proteome; Repeat; Transport; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1218 AA 
Protein Sequence
MLTKFETKSN RVKGLSFHPR RPWILASLHS GVIQMWDYRM GTLLDRFDEH DGPVRGVHFH 60
ATQPLFVSGG DDYKIKVWNY KTHRCLFTLH GHLDYIRTVQ FHHEYPWIVS ASDDQTIRIW 120
NWQSRTCVAV LTGHNHYVMC ASFHPKEDLV VSASLDQTVR VWDIGALRKK TVSPADDILR 180
LTQMNTDLFG GVDAVVKYVL EGHDRGVNWA SFHPTLPLIV SGADDRQVKL WRMNDTKAWE 240
VDTLRGHMNN VSCVMFHAKQ DIIVSNSEDK SIRIWDATKR TGIQTFRREH DRFWILSAHP 300
EMNLLAAGHD SGMIVFKLER ERPAFSVSGD TVFYVKDRFL RFFEFTTQKE VQLAPIRRPG 360
SVSLNQSPKT LSYSPTENAV LICSDVDGGS YELYIVPKDS AGRADYLQDA KKGAGGSAVF 420
VARNRFAVLE KSSNQVLVKN LKNEIVKKSP LPIATDAIYY AGTGNLLCKA EDRVTIFDLQ 480
QRLILGELQA PSVKYVVWSS DMESVALLSK HAVVIANKKL VHRCTLHETI RVKSGAWDEN 540
GVFIYTTLNH IKYCLPNGDS GIIKTLDVPI YITRVIGNNI FCLDRDGKNK LVTVDASEYI 600
FKLALLRKRY DHVMSMIKNS QLCGQAVISY LQQKGFPEVA LHFVKDEKTR FNLALESGNI 660
QIAVASAKEI DDKDHWYRLG IEALRQGNVG IVEYAYQRTK NFERLAFLYL ITGYMDKVGF 720
MCKIAGQNNN LMGQFHNALY LGDALKRVEI LENAGQLPLA YITATTHGLT EIADRLAAEL 780
GENIPSLPEG KARSLLIPPA PLTASGDWPL LRVMHGIFEG GLDATGKAEL EEDDEAAGAD 840
WGDEDLDMVD ASEAMANGGD GFDAEEGEAN EEDGEEGGWD LEDLELPPEA ETPKNAGNAR 900
SAVFVAPPPG MPVSLIWTQK SSLAGEHAAA GNFDTAMRLL SRQLGIKNFA PLKPLFVDLH 960
MGSHSYLRAL ATAPIIPIAV EKGWSESASP NVRGPPALVF TFPQMEDRLK AAYKATTDGK 1020
FPEALRQFLS ILHTIPLIVV DSRREVDEVK ELIEIVREYV LGLRMELKRK ELRDDVNRQQ 1080
ELAAYFTNCK LQRVHMRLVL GSAMGLCYKQ KNFATAEHFA RMLLENNPNE AQARRARQVQ 1140
QQCSGKKDSS ELNYDYRNPF VVCGATYVPI YRGQKDVSCP YCGSRFVPSI EGQLCTICEL 1200
AVVGADASGL LCSPTQSR 1218 
Gene Ontology
 GO:0030126; C:COPI vesicle coat; IEA:InterPro.
 GO:0005886; C:plasma membrane; IEA:EnsemblPlants/Gramene.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW. 
Interpro
 IPR016391; Coatomer_asu.
 IPR010714; Coatomer_asu_C.
 IPR006692; Coatomer_WD-assoc_reg.
 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF04053; Coatomer_WDAD
 PF06957; COPI_C
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.