CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013127
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hepatoma-derived growth factor-related protein 2 
Protein Synonyms/Alias
 HRP-2 
Gene Name
 Hdgfrp2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
6**MPHAFKPGDLVFAacetylation[1]
39AVKPPPNKYPIFFFGacetylation[1]
63KDLFPYDKCKDKYGKubiquitination[2]
483SEIKFALKVDNPDVRubiquitination[3]
520TDVVATLKKIRRYKAubiquitination[3]
550KSRVLGPKVEALQKVacetylation[4]
550KSRVLGPKVEALQKVubiquitination[3]
556PKVEALQKVNKAGAEubiquitination[3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Associates with chromatin. Isoform 1 and isoform 3 bind to condensed chromatin in mitotic cells. Isoform 4 binds to non- condensed chromatin in the presence of HDGF. 
Sequence Annotation
 DOMAIN 7 64 PWWP.
 MOD_RES 137 137 Phosphoserine (By similarity).
 MOD_RES 229 229 Phosphoserine (By similarity).
 MOD_RES 231 231 Phosphoserine.
 MOD_RES 233 233 Phosphoserine.
 MOD_RES 235 235 Phosphoserine.
 MOD_RES 239 239 Phosphoserine (By similarity).
 MOD_RES 366 366 Phosphoserine.
 MOD_RES 367 367 Phosphoserine.
 MOD_RES 389 389 Phosphothreonine.
 MOD_RES 391 391 Phosphoserine.
 MOD_RES 392 392 Phosphoserine.
 MOD_RES 393 393 Phosphoserine.
 MOD_RES 395 395 Phosphoserine.
 MOD_RES 450 450 Phosphoserine.
 MOD_RES 620 620 Phosphoserine.
 MOD_RES 628 628 Phosphoserine.
 MOD_RES 629 629 Phosphoserine (By similarity).
 MOD_RES 635 635 Phosphoserine.
 MOD_RES 640 640 Phosphoserine.
 MOD_RES 659 659 Phosphoserine.
 MOD_RES 661 661 Phosphoserine.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 669 AA 
Protein Sequence
MPHAFKPGDL VFAKMKGYPH WPARIDDIAD GAVKPPPNKY PIFFFGTHET AFLGPKDLFP 60
YDKCKDKYGK PNKRKGFNEG LWEIQNNPHA SYSAPPPVSS SDSEAPEADL GCGSDVDKDK 120
ESRRVMTVTA VTTTATSDRM ESDSDSDKSS DHSGLKRKTP VLKVSVSKRA RRASSDLDQA 180
SVSPSEEDSE SPSESEKTSD QDFTPEKKTA ARPPRRGPLG GRKKKKVPSA SDSDSKADSD 240
GAKEEPVVTA QPSPSSSSSS SSSSSSDSDV SVKKPPRGRK PAEKPPPKPR GRRPKPERPP 300
STSSSDSDSD SGEVDRISEW KRRDEERRRE LEARRRREQE EELRRLREQE REEKERRKER 360
AERGGSSGEE LEDEEPVKKR SRKARGRGTP SSSDSEPEGE LGKEGKKLAK KSQLPGSESA 420
RKPGQKEKRG RPDEKPRARP VKVERTRKRS EGLSLERKGE KKKEPSVEER LQKLHSEIKF 480
ALKVDNPDVR KCLSALEELG TLQVTSQILQ KNTDVVATLK KIRRYKANKD VMAKAAEVYT 540
RLKSRVLGPK VEALQKVNKA GAEKERADNE KLEEQPGEQA PRELAEDEPS TDRSAPVNGE 600
ATSQKGENME DRAQEDGQDS EDGPRGGSSE ELHDSPRDNS DPAKPGNERQ DHERTRLASE 660
SANDDNEDS 669 
Gene Ontology
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR021567; LEDGF.
 IPR000313; PWWP.
 IPR017923; TFIIS_N. 
Pfam
 PF11467; LEDGF
 PF00855; PWWP 
SMART
 SM00293; PWWP 
PROSITE
 PS50812; PWWP 
PRINTS