| Tag | Content |
|---|
| CPLM ID | CPLM-016066 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | CAAX prenyl protease 1 homolog |
Protein Synonyms/Alias | Farnesylated proteins-converting enzyme 1; FACE-1; Prenyl protein-specific endoprotease 1; Zinc metalloproteinase Ste24 homolog |
Gene Name | Zmpste24 |
Gene Synonyms/Alias | Face1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 251 | SIDFPLTKVYVVEGS | ubiquitination | [1] | | 429 | AKKLGKAKDLYSALI | ubiquitination | [1] | | 437 | DLYSALIKLNKDNLG | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C. |
Sequence Annotation | ACT_SITE 336 336 By similarity.
ACT_SITE 419 419 Proton donor (By similarity).
METAL 335 335 Zinc; catalytic (By similarity).
METAL 339 339 Zinc; catalytic (By similarity).
METAL 415 415 Zinc; catalytic (By similarity). |
Keyword | Complete proteome; Endoplasmic reticulum; Hydrolase; Membrane; Metal-binding; Metalloprotease; Nucleus; Protease; Reference proteome; Transmembrane; Transmembrane helix; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 475 AA |
Protein Sequence | MGMWASVDAM WDFPAEKRIF GAVLLFSWTV YLWETFLAQR QRRIYKTTTR VPAELEQIMD 60
SDTFEKSRLY QLDKSTFSFW SGLYSEVEGT FILLFGGIPY LWRLSGQFCS SAGFGPEYEI 120
IQSLVFLLLA TLFSALTGLP WSLYNTFVIE EKHGFNHQTL EFFMKDAIKK FIVTQCILLP 180
VSALLLYIIK IGGDYFFIYA WLFTLVVSLV LVTIYADYIA PLFDKFTPLP EGKLKQEIEV 240
MAKSIDFPLT KVYVVEGSKR SSHSNAYFYG FFKNKRIVLF DTLLEEYSVP NKDNQEESGM 300
EARNEGEGDS EEVKAKVKNK KQGCKNEEVL AVLGHELGHW KLGHTVKNII ISQMNSFLCF 360
FLFAVLIGRR ELFAAFGFYD SQPTLIGLLI IFQFIFSPYN EVLSFCLTVL SRRFEFQADA 420
FAKKLGKAKD LYSALIKLNK DNLGFPVSDW LFSTWHYSHP PLLERLQALK NAKQD 475 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0016020; C:membrane; IDA:MGI. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004222; F:metalloendopeptidase activity; IDA:MGI. GO:0071586; P:CAAX-box protein processing; IEA:InterPro. GO:0006998; P:nuclear envelope organization; IMP:MGI. GO:0030327; P:prenylated protein catabolic process; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |