CPLM-009423

Genbank Nucleotide ID

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

Protein Synonyms/Alias

Rattus norvegicus (Rat)

Position	Peptide	Type	References
6	**MSDSEKLNLDSII	acetylation	[1]
26	VQGSRPGKNVQLTEN	ubiquitination	[2]
147	CKRRYNIKLWKTFTD	acetylation	[1]

[1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
[2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]

Functional Description

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development (By similarity).

ACT_SITE 125 125 Proton donor (By similarity).
METAL 64 64 Iron (By similarity).
METAL 66 66 Iron (By similarity).
METAL 92 92 Iron (By similarity).
METAL 92 92 Manganese (By similarity).
METAL 124 124 Manganese (By similarity).
METAL 173 173 Manganese (By similarity).
METAL 248 248 Manganese (By similarity).
MOD_RES 2 2 N-acetylserine (By similarity).
MOD_RES 306 306 Phosphotyrosine (By similarity).
MOD_RES 320 320 Phosphothreonine (By similarity).

Acetylation; Carbohydrate metabolism; Cell cycle; Cell division; Complete proteome; Cytoplasm; Direct protein sequencing; Glycogen metabolism; Hydrolase; Iron; Manganese; Metal-binding; Nucleus; Phosphoprotein; Protein phosphatase; Reference proteome.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005829; C:cytosol; TAS:Reactome.
GO:0043197; C:dendritic spine; IDA:RGD.
GO:0042587; C:glycogen granule; IDA:RGD.
GO:0070688; C:MLL5-L complex; IEA:Compara.
GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
GO:0005634; C:nucleus; IDA:RGD.
GO:0043204; C:perikaryon; IDA:RGD.
GO:0000164; C:protein phosphatase type 1 complex; IDA:RGD.
GO:0072357; C:PTW/PP1 phosphatase complex; ISS:UniProtKB.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004721; F:phosphoprotein phosphatase activity; IDA:RGD.
GO:0004722; F:protein serine/threonine phosphatase activity; IEA:Compara.
GO:0043021; F:ribonucleoprotein complex binding; IPI:RGD.
GO:0048754; P:branching morphogenesis of an epithelial tube; IEA:Compara.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-KW.
GO:0030324; P:lung development; IEA:Compara.
GO:0006470; P:protein dephosphorylation; IDA:RGD.
GO:0005979; P:regulation of glycogen biosynthetic process; IDA:RGD.
GO:0005981; P:regulation of glycogen catabolic process; IDA:RGD.

IPR004843; Metallo_PEstase_dom.
IPR006186; Ser/Thr-sp_prot-phosphatase.

PF00149; Metallophos

PS00125; SER_THR_PHOSPHATASE

PR00114; STPHPHTASE.