| Tag | Content |
|---|
| CPLM ID | CPLM-018625 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | KH domain-containing, RNA-binding, signal transduction-associated protein 2 |
Protein Synonyms/Alias | Sam68-like mammalian protein 1; SLM-1; rSLM-1 |
Gene Name | Khdrbs2 |
Gene Synonyms/Alias | Slm1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 47 | GRKEDEEKKYLDVIS | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. May function as an adapter protein for Src kinases during mitosis (By similarity). Binds both poly(A) and poly(U) homopolymers (By similarity). Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). |
Sequence Annotation | DOMAIN 65 135 KH. |
Keyword | Complete proteome; Methylation; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; SH3-binding; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 349 AA |
Protein Sequence | MGEEKYLPEL MAEKDSLDPS FVHASRLLAE EIEKFQGSDG RKEDEEKKYL DVISNKNIKL 60
SERVLIPVKQ YPKFNFVGKL LGPRGNSLKR LQEETGAKMS ILGKGSMRDK AKEEELRKSG 120
EAKYAHLSDE LHVLIEVFAP PGEAYSRMSH ALEEIKKFLV PDYNDEIRQE QLRELSYLNG 180
SEESGRGRGI RGRGIRITPT APSRGRGGAV PPPPPPGRGV LTPRGTTVTR GALPVPPVAR 240
GVPTPRARGT AAVPGYRAPP PPAPEAYEEY GYDDGYGGEY DDQTYEAYDN SYVTPTQSVP 300
EYYDYGHGVN EDAYDSYAPE EWTTTRSSLK APPPRSARGG YREHPYGRY 349 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0008143; F:poly(A) RNA binding; IEA:Compara. GO:0008266; F:poly(U) RNA binding; IEA:Compara. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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