CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014297
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Segment polarity protein dishevelled homolog DVL-3 
Protein Synonyms/Alias
 Dishevelled-3; DSH homolog 3 
Gene Name
 Dvl3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
34RVTLADFKGVLQRPSubiquitination[1]
466TDRREARKYASNLLKubiquitination[1]
473KYASNLLKAGFIRHTubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May play a role in the signal transduction pathway mediated by multiple Wnt genes. 
Sequence Annotation
 DOMAIN 1 82 DIX.
 DOMAIN 249 321 PDZ.
 DOMAIN 422 496 DEP.
 MOD_RES 27 27 Omega-N-methylarginine (By similarity).
 MOD_RES 48 48 Phosphoserine (By similarity).
 MOD_RES 192 192 Phosphoserine (By similarity).
 MOD_RES 212 212 Omega-N-methylarginine (By similarity).
 MOD_RES 342 342 Omega-N-methylarginine (By similarity).
 MOD_RES 346 346 Phosphothreonine (By similarity).
 MOD_RES 698 698 Dimethylated arginine; alternate (By
 MOD_RES 698 698 Omega-N-methylarginine; alternate (By
 MOD_RES 700 700 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Developmental protein; Methylation; Phosphoprotein; Reference proteome; Ubl conjugation; Wnt signaling pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 716 AA 
Protein Sequence
MGETKIIYHL DGQETPYLVK LPLPAERVTL ADFKGVLQRP SYKFFFKSMD DDFGVVKEEI 60
SDDNAKLPCF NGRVVSWLVS AEGSHPEPAP FCADNPSELP PSMERTGGIG DSRPPSFHPH 120
ASGGSQENLD NDTETDSLVS AQRERPRRRD GPEHAARLNG TTKGERRREP GGYDSSSTLM 180
SSELETTSFF DSDEDDSTSR FSSSTEQSSA SRLMRRHKRR RRKQKVSRIE RSSSFSSITD 240
STMSLNIITV TLNMEKYNFL GISIVGQSNE RGDGGIYIGS IMKGGAVAAD GRIEPGDMLL 300
QVNEINFENM SNDDAVRVLR EIVHKPGPIT LTVAKCWDPS PRGCFTLPRS EPIRPIDPAA 360
WVSHTAAMTG TFPAYGMSPS LSTITSTSSS ITSSIPDTER LDDFHLSIHS DMAAIVKAMA 420
SPESGLEVRD RMWLKITIPN AFIGSDVVDW LYHNVEGFTD RREARKYASN LLKAGFIRHT 480
VNKITFSEQC YYIFGDLCGN MANLSLHDHD GSSGASDQDT LAPLPHPGAA PWPMAFPYQY 540
PPPPHPYNPH PGFPELGYSY GGGSASSQHS EGSRSSGSNR SGSDRRKEKD PKAGDSKSGG 600
SGSESDHTTR SSLRGPRERA PSERSGPAAS EHSHRSHHSL TSSLRSHHTH PSYGPPGVPP 660
LYGPPMLMMT PPPAAMGPPG APPGRDLASV PPELTASRQS FRMAMGNPSE FFVDVM 716 
Gene Ontology
 GO:0005938; C:cell cortex; IBA:RefGenome.
 GO:0008013; F:beta-catenin binding; IBA:RefGenome.
 GO:0005109; F:frizzled binding; IBA:RefGenome.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0060070; P:canonical Wnt receptor signaling pathway; TAS:BHF-UCL.
 GO:0090103; P:cochlea morphogenesis; IGI:MGI.
 GO:0060026; P:convergent extension; IBA:RefGenome.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0038031; P:non-canonical Wnt receptor signaling pathway via JNK cascade; IDA:BHF-UCL.
 GO:0003148; P:outflow tract septum morphogenesis; IMP:MGI.
 GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IGI:MGI.
 GO:0043507; P:positive regulation of JUN kinase activity; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IBA:RefGenome.
 GO:0023051; P:regulation of signaling; IBA:RefGenome.
 GO:0042493; P:response to drug; IEA:Compara. 
Interpro
 IPR000591; DEP_dom.
 IPR008342; Dishevelled_3.
 IPR024580; Dishevelled_C-dom.
 IPR008339; Dishevelled_fam.
 IPR003351; Dishevelled_protein_dom.
 IPR001158; DIX.
 IPR015506; Dsh/Dvl-rel.
 IPR001478; PDZ.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00610; DEP
 PF02377; Dishevelled
 PF00778; DIX
 PF12316; Dsh_C
 PF00595; PDZ 
SMART
 SM00021; DAX
 SM00049; DEP
 SM00228; PDZ 
PROSITE
 PS50186; DEP
 PS50841; DIX
 PS50106; PDZ 
PRINTS
 PR01760; DISHEVELLED.
 PR01763; DISHEVELLED3.