UniProt Accession

 GLRB_MOUSE; P48168; Q5U5X3 

Genbank Protein ID

 U09399; X81202; X81201; L32594; AK083251; CH466547; BC037605 

Genbank Nucleotide ID

 AAA61874.1; CAA57076.1; CAA57075.1; AAA65966.1; BAC38831.1; EDL15445.1; AAH37605.1 

Protein Name

 Glycine receptor subunit beta 

Protein Synonyms/Alias

 Glycine receptor 58 kDa subunit 

Gene Name

 Glrb 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
117	KWNDPRLKLPSDFRG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing). 

Sequence Annotation

 CARBOHYD 54 54 N-linked (GlcNAc...) (Potential).
 CARBOHYD 242 242 N-linked (GlcNAc...) (Potential).
 DISULFID 183 197 By similarity.  

Keyword

 Cell junction; Cell membrane; Chloride; Chloride channel; Complete proteome; Disease mutation; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 496 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
 GO:0005783; C:endoplasmic reticulum; ISA:MGI.
 GO:0009897; C:external side of plasma membrane; ISA:MGI.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0016934; F:extracellular-glycine-gated chloride channel activity; IMP:MGI.
 GO:0016594; F:glycine binding; IMP:MGI.
 GO:0007340; P:acrosome reaction; IMP:MGI.
 GO:0007628; P:adult walking behavior; IMP:MGI.
 GO:0007399; P:nervous system development; ISS:UniProtKB.
 GO:0007218; P:neuropeptide signaling pathway; ISS:UniProtKB.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0042391; P:regulation of membrane potential; IMP:MGI.
 GO:0060013; P:righting reflex; IMP:MGI.
 GO:0001964; P:startle response; ISS:UniProtKB.
 GO:0060012; P:synaptic transmission, glycinergic; IMP:MGI.
 GO:0007601; P:visual perception; IMP:MGI. 

Interpro

 IPR008060; Glycine_rcpt_B.
 IPR006202; Neur_chan_lig-bd.
 IPR006201; Neur_channel.
 IPR006029; Neurotrans-gated_channel_TM.
 IPR018000; Neurotransmitter_ion_chnl_CS. 

Pfam

 PF02931; Neur_chan_LBD
 PF02932; Neur_chan_memb 

SMART

  

PROSITE

 PS00236; NEUROTR_ION_CHANNEL 

PRINTS

 PR01677; GLYRBETA.
 PR00252; NRIONCHANNEL.