CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034246
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Dimethylaniline monooxygenase [N-oxide-forming] 1 
Protein Synonyms/Alias
  
Gene Name
 Fmo1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
56EGRASLYKSVVSNSSubiquitination[1]
109RCIYFNTKVCSITKRacetylation[2]
115TKVCSITKRPDFAVSubiquitination[1]
208VEASHLAKK******ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; FAD; Flavoprotein; Monooxygenase; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 209 AA 
Protein Sequence
MVKRVAIVGA GVSGLASIKC CLEEGLEPTC FERSSDLGGL WRFTEHVEEG RASLYKSVVS 60
NSSREMSCYP DFPFPEDYPN FVPNSLFLEY LKLYSTQFNL QRCIYFNTKV CSITKRPDFA 120
VSGQWEVVTV TNGKQNSAIF DAVMVCTGFL TNPHLPLDSF PGILTFKGEY FHSRQYKHPD 180
IFKDKRVLVV GMGNSGTDIA VEASHLAKK 209 
Gene Ontology
 GO:0043231; C:intracellular membrane-bounded organelle; IEA:Compara.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0004499; F:N,N-dimethylaniline monooxygenase activity; IEA:Compara.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0070995; P:NADPH oxidation; IEA:Compara.
 GO:0006082; P:organic acid metabolic process; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0006970; P:response to osmotic stress; IEA:Compara.
 GO:0009404; P:toxin metabolic process; IEA:Compara. 
Interpro
 IPR000960; Flavin_mOase.
 IPR020946; Flavin_mOase-like.
 IPR002253; Flavin_mOase_1. 
Pfam
 PF00743; FMO-like 
SMART
  
PROSITE
  
PRINTS
 PR00370; FMOXYGENASE.
 PR01121; FMOXYGENASE1.