CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036385
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46, isoform CRA_b 
Protein Synonyms/Alias
 Probable ATP-dependent RNA helicase DDX46 
Gene Name
 DDX46 
Gene Synonyms/Alias
 hCG_16595 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
223VVTVVTTKKAVVDSDubiquitination[1]
231KAVVDSDKKKGELMEacetylation[2]
369RDLIGIAKTGSGKTIubiquitination[1]
374IAKTGSGKTIAFLLPubiquitination[1]
445SEQIAELKRGAEIIVubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 471 AA 
Protein Sequence
MGRESRHYRK RSASRGRSGS RSRSRSPSDK RSKRGDDRRS RSRDRDRRRE RSRSRDKRRS 60
RSRDRKRLRS RSKEKTDGGE SSKEKKKDKD DKEDEKEKDA GNFDQNKLEE EMRKRKERVE 120
KWREEQRKKA MENIGELKKE IEEMKQGKKW SLEDDDDDED DPAEAEKEGN EMEGEELDPL 180
DAYMEEVKEE VKKFNMRSVK GGGGNEKKSG PTVTKVVTVV TTKKAVVDSD KKKGELMEND 240
QDAMEYSSEE EEVDLQTALT GYQTKQRKLL EPVDHGKIEY EPFRKNFYVE VPELAKMSQE 300
EVNVFRLEME GITVKGKGCP KPIKSWVQCG ISMKILNSLK KHGYEKPTPI QTQAIPAIMS 360
GRDLIGIAKT GSGKTIAFLL PMFRHIMDQR SLEEGEGPIA VIMTPTRELA LQITKECKKF 420
SKTLGLRVVC VYGGTGISEQ IAELKRGAEI IVCTPGRMID MLAANSGDAV R 471 
Gene Ontology
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro. 
Interpro
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR014001; Helicase_ATP-bd.
 IPR027417; P-loop_NTPase.
 IPR014014; RNA_helicase_DEAD_Q_motif. 
Pfam
 PF00270; DEAD 
SMART
 SM00487; DEXDc 
PROSITE
 PS51192; HELICASE_ATP_BIND_1
 PS51195; Q_MOTIF 
PRINTS