UniProt Accession

 6PGD_ECOLI; P00350; P78080; Q47571; Q59366; Q59402; Q59411; Q59412; Q59413; Q59414; Q59416; Q79DT3 

Genbank Protein ID

 K02072; M63821; M64326; M64327; M64328; M64329; M64330; M64331; U00096; AP009048; M23181; M18956; M18957; M18960; AF125322 

Genbank Nucleotide ID

 AAA23918.1; AAA24488.1; AAA24204.1; AAA24205.1; AAA24206.1; AAA24207.1; AAA24208.1; AAA24209.1; AAC75090.1; BAA15869.1; AAA23924.1; AAA23919.1; AAA23920.1; AAA23922.1; AAC27540.1 

Protein Name

 6-phosphogluconate dehydrogenase, decarboxylating 

Protein Synonyms/Alias

  

Gene Name

 gnd 

Gene Synonyms/Alias

 b2029; JW2011 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
38	IFNRSREKTEEVIAE	acetylation	[1, 2]
49	VIAENPGKKLVPYYT	acetylation	[2]
50	IAENPGKKLVPYYTV	acetylation	[1, 2]
58	LVPYYTVKEFVESLE	acetylation	[1, 2]
75	RRILLMVKAGAGTDA	acetylation	[1]
88	DAAIDSLKPYLDKGD	acetylation	[2]
93	SLKPYLDKGDIIIDG	acetylation	[2]
136	GGEEGALKGPSIMPG	acetylation	[2]
146	SIMPGGQKEAYELVA	acetylation	[2]
158	LVAPILTKIAAVAED	acetylation	[1]
242	TKDIFTKKDEDGNYL	acetylation	[2]
260	ILDEAANKGTGKWTS	acetylation	[1, 2]
264	AANKGTGKWTSQSAL	acetylation	[1, 2]
301	DQRVAASKVLSGPQA	acetylation	[1, 2]
314	QAQPAGDKAEFIEKV	acetylation	[2]
320	DKAEFIEKVRRALYL	acetylation	[1, 2]
358	LNYGEIAKIFRAGCI	acetylation	[2]
454	YFGAHTYKRIDKEGV	acetylation	[1, 2]
458	HTYKRIDKEGVFHTE	acetylation	[2]

Reference

 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. 

Sequence Annotation

 NP_BIND 10 15 NADP.
 NP_BIND 33 35 NADP.
 NP_BIND 74 76 NADP.
 REGION 128 130 Substrate binding.
 REGION 186 187 Substrate binding (By similarity).
 ACT_SITE 183 183 Proton acceptor.
 ACT_SITE 190 190 Proton donor.
 BINDING 102 102 NADP (By similarity).
 BINDING 102 102 Substrate.
 BINDING 191 191 Substrate (By similarity).
 BINDING 260 260 Substrate; via amide nitrogen.
 BINDING 287 287 Substrate.
 BINDING 445 445 Substrate; shared with dimeric partner.
 BINDING 451 451 Substrate; shared with dimeric partner.  

Keyword

 3D-structure; Complete proteome; Gluconate utilization; NADP; Oxidoreductase; Pentose shunt; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 468 AA 

Protein Sequence

Gene Ontology

 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0004616; F:phosphogluconate dehydrogenase (decarboxylating) activity; IDA:UniProtKB.
 GO:0019521; P:D-gluconate metabolic process; IEA:UniProtKB-KW.
 GO:0006098; P:pentose-phosphate shunt; IDA:UniProtKB. 

Interpro

 IPR008927; 6-PGluconate_DH_C-like.
 IPR006114; 6PGDH_C.
 IPR006113; 6PGDH_decarbox.
 IPR006115; 6PGDH_NADP-bd.
 IPR006184; 6PGdom_BS.
 IPR013328; DH_multihelical.
 IPR012284; Fibritin/6PGD_C-extension.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF00393; 6PGD
 PF03446; NAD_binding_2 

SMART

  

PROSITE

 PS00461; 6PGD 

PRINTS