UniProt Accession

 DHSO_RAT; P27867; A2VCV9; Q4FZY4; Q5I0F3 

Genbank Protein ID

 X59037; X74593; BC088398; BC098919; BC128707 

Genbank Nucleotide ID

 CAA41761.1; CAA52670.1; AAH88398.2; AAH98919.2; AAI28708.2 

Protein Name

 Sorbitol dehydrogenase 

Protein Synonyms/Alias

 L-iditol 2-dehydrogenase 

Gene Name

 Sord 

Gene Synonyms/Alias

 Sdh1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
6	**MAAPAKGENLSLV	acetylation	[1]
63	RIGDFVVKKPMVLGH	acetylation	[1]
78	EAAGTVTKVGPMVKH	acetylation	[1]
234	ETPHDIAKKVESVLG	acetylation	[1]
319	ASKTLNVKPLVTHRF	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm (By similarity). 

Sequence Annotation

 METAL 45 45 Zinc; catalytic (By similarity).
 METAL 70 70 Zinc; catalytic (By similarity).
 METAL 71 71 Zinc; catalytic (By similarity).
 BINDING 51 51 Substrate (By similarity).
 BINDING 156 156 Substrate (By similarity).
 BINDING 299 299 Substrate (By similarity).
 BINDING 300 300 Substrate (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 169 169 Phosphoserine (By similarity).  

Keyword

 Acetylation; Cell projection; Cilium; Complete proteome; Flagellum; Membrane; Metal-binding; Mitochondrion; NAD; Oxidoreductase; Phosphoprotein; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 357 AA 

Protein Sequence

Gene Ontology

 GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
 GO:0031514; C:motile cilium; ISS:UniProtKB.
 GO:0042802; F:identical protein binding; IDA:RGD.
 GO:0003939; F:L-iditol 2-dehydrogenase activity; IEA:EC.
 GO:0008270; F:zinc ion binding; IDA:RGD.
 GO:0046686; P:response to cadmium ion; IDA:RGD.
 GO:0046688; P:response to copper ion; IDA:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0009725; P:response to hormone stimulus; IDA:RGD.
 GO:0031667; P:response to nutrient levels; IEP:RGD.
 GO:0006970; P:response to osmotic stress; IEP:RGD.
 GO:0030317; P:sperm motility; ISS:UniProtKB. 

Interpro

 IPR013149; ADH_C.
 IPR013154; ADH_GroES-like.
 IPR002085; ADH_SF_Zn-type.
 IPR002328; ADH_Zn_CS.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF08240; ADH_N
 PF00107; ADH_zinc_N 

SMART

  

PROSITE

 PS00059; ADH_ZINC 

PRINTS