CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007839
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kinesin light chain 
Protein Synonyms/Alias
 KLC 
Gene Name
 Klc 
Gene Synonyms/Alias
 CG5433 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
366NLAGCYLKQGRYTEAacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity. 
Sequence Annotation
 REPEAT 186 219 TPR 1.
 REPEAT 228 261 TPR 2.
 REPEAT 270 303 TPR 3.
 REPEAT 312 345 TPR 4.
 REPEAT 354 387 TPR 5.
 REPEAT 437 470 TPR 6.
 MOD_RES 168 168 Phosphothreonine.
 MOD_RES 477 477 Phosphothreonine.
 MOD_RES 480 480 Phosphoserine.
 MOD_RES 485 485 Phosphoserine.  
Keyword
 Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Motor protein; Phosphoprotein; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 508 AA 
Protein Sequence
MTQMSQDEII TNTKTVLQGL EALRVEHVSI MNGIAEVQKD NEKSDMLRKN IENIELGLSE 60
AQVMMALTSH LQNIEAEKHK LKTQVRRLHQ ENAWLRDELA NTQQKFQASE QLVAQLEEEK 120
KHLEFMASVK KYDENQEQDD ACDKSRTDPV VELFPDEENE DRHNMSPTPP SQFANQTSGY 180
EIPARLRTLH NLVIQYASQG RYEVAVPLCK QALEDLERTS GHDHPDVATM LNILALVYRD 240
QNKYKEAANL LNDALSIRGK TLGENHPAVA ATLNNLAVLY GKRGKYKDAE PLCKRALEIR 300
EKVLGKDHPD VAKQLNNLAL LCQNQGKYDE VEKYYQRALD IYESKLGPDD PNVAKTKNNL 360
AGCYLKQGRY TEAEILYKQV LTRAHEREFG AIDSKNKPIW QVAEEREEHK FDNRENTPYG 420
EYGGWHKAAK VDSPTVTTTL KNLGALYRRQ GMFEAAETLE DCAMRSKKEA YDLAKQTKLS 480
QLLTSNEKRR SKAIKEDLDF SEEKNAKP 508 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005871; C:kinesin complex; ISS:FlyBase.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0003777; F:microtubule motor activity; IDA:FlyBase.
 GO:0007018; P:microtubule-based movement; IDA:FlyBase.
 GO:0051726; P:regulation of cell cycle; IDA:FlyBase. 
Interpro
 IPR002151; Kinesin_light.
 IPR015792; Kinesin_light_repeat.
 IPR015390; Rabaptin_Rab5-bd_dom.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR019734; TPR_repeat. 
Pfam
 PF09311; Rab5-bind
 PF00515; TPR_1
 PF07719; TPR_2 
SMART
 SM00028; TPR 
PROSITE
 PS01160; KINESIN_LIGHT
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS
 PR00381; KINESINLIGHT.