CPLM-014016

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-014016

UniProt Accession

INT11_HUMAN; Q5TA45; A8K5S2; B3KPR3; B4DM87; G3V1S5; Q5TA46; Q5TA48; Q5TA52; Q5TA53; Q5TA54; Q7L3D7; Q96HY1; Q9BW36; Q9H0F9; Q9H8R5; Q9HAA6; Q9NWX9

Genbank Protein ID

AL136813; AK000549; AK021939; AK023356; AK056652; AK291387; AK297350; CR533557; AL139287; AL139287; AL139287; AL139287; AL139287; AL139287; CH471183; BC000675; BC007978; BC013904; BK005728; BK005673

Genbank Nucleotide ID

CAB66747.1; BAA91246.1; BAB13943.1; BAB14541.1; BAG51775.1; BAF84076.1; BAG59799.1; CAG38588.1; CAI23174.1; CAI23176.1; CAI23177.1; CAI23179.1; CAI23180.1; CAI23181.1; EAW56238.1; AAH00675.2; AAH07978.1; AAH13904.2; DAA05728.1; DAA05669.1

Protein Name

Integrator complex subunit 11

Protein Synonyms/Alias

Int11; Cleavage and polyadenylation-specific factor 3-like protein; CPSF3-like protein; Protein related to CPSF subunits of 68 kDa; RC-68

Gene Name

CPSF3L

Gene Synonyms/Alias

INTS11; RC68

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
133	ETVERGGKVLIPVFA	ubiquitination	[1]
161	FWERMNLKVPIYFST	ubiquitination	[1]
399	VSSEQALKELGLAEH	ubiquitination	[1]

Reference

[1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage.

Sequence Annotation

MOTIF 68 73 HXHXDH motif.

Keyword

Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Nucleus; Reference proteome.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

600 AA

Protein Sequence

MPEIRVTPLG AGQDVGRSCI LVSIAGKNVM LDCGMHMGFN DDVDDELEIK AYYAGHVLGA 60
AMFQIKVGSE SVVYTGDYNM TPDRHLGAAW IDKCRPNLLI TESTYATTIR DSKRCRERDF 120
LKKVHETVER GGKVLIPVFA LGRAQELCIL LETFWERMNL KVPIYFSTGL TEKANHYYKL 180
FIPWTNQKIR KTFVQRNMFE FKHIKAFDRA FADNPGPMVV FATPGMLHAG QSLQIFRKWA 240
GNEKNMVIMP GYCVQGTVGH KILSGQRKLE MEGRQVLEVK MQVEYMSFSA HADAKGIMQL 300
VGQAEPESVL LVHGEAKKME FLKQKIEQEL RVNCYMPANG ETVTLPTSPS IPVGISLGLL 360
KREMAQGLLP EAKKPRLLHG TLIMKDSNFR LVSSEQALKE LGLAEHQLRF TCRVHLHDTR 420
KEQETALRVY SHLKSVLKDH CVQHLPDGSV TVESVLLQAA APSEDPGTKV LLVSWTYQDE 480
ELGSFLTSLL KKGLPQAPS 499

Gene Ontology

GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.

Interpro

IPR001279; Beta-lactamas-like.
IPR022712; Beta_Casp.
IPR011108; RMMBL.

Pfam

PF10996; Beta-Casp
PF00753; Lactamase_B
PF07521; RMMBL

SMART

SM01027; Beta-Casp
SM00849; Lactamase_B

PROSITE

PRINTS