UniProt Accession

 PCY1_YEAST; P13259; D6VUY4 

Genbank Protein ID

 M36827; Z49133; Z72987; AY557840; BK006941 

Genbank Nucleotide ID

 AAA91962.1; CAA88995.1; CAA97229.1; AAS56166.1; DAA08295.1 

Protein Name

 Choline-phosphate cytidylyltransferase 

Protein Synonyms/Alias

 CTP:phosphocholine cytidylyltransferase; CCT; CT; Phosphorylcholine transferase 

Gene Name

 PCT1 

Gene Synonyms/Alias

 CCT; CCT1; YGR202C; G7729 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
14	GKSSIRAKLSNSSLS	acetylation	[1]
235	STSDIITKIIRDYDK	ubiquitination	[2]
314	LGKKLYSKLIGNELK	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Identification, analysis, and prediction of protein ubiquitination sites.
 Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM.
 Proteins. 2010 Feb 1;78(2):365-80. [PMID: 19722269] 

Functional Description

  

Sequence Annotation

 NP_BIND 111 119 CTP (By similarity).
 NP_BIND 195 196 CTP (By similarity).
 NP_BIND 223 227 CTP (By similarity).
 BINDING 149 149 CTP (By similarity).
 BINDING 149 149 Substrate (By similarity).
 BINDING 178 178 Substrate (By similarity).
 BINDING 200 200 CTP (By similarity).
 MOD_RES 16 16 Phosphoserine.
 MOD_RES 59 59 Phosphothreonine.
 MOD_RES 346 346 Phosphoserine.
 MOD_RES 401 401 Phosphoserine; by CK2 (Potential).  

Keyword

 Complete proteome; Lipid biosynthesis; Lipid metabolism; Membrane; Nucleotidyltransferase; Phospholipid biosynthesis; Phospholipid metabolism; Phosphoprotein; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 424 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; TAS:SGD.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005635; C:nuclear envelope; IDA:SGD.
 GO:0004105; F:choline-phosphate cytidylyltransferase activity; IDA:SGD. 

Interpro

 IPR004821; Cyt_trans-like.
 IPR014729; Rossmann-like_a/b/a_fold. 

Pfam

 PF01467; CTP_transf_2 

SMART

  

PROSITE

  

PRINTS