CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041275
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dipeptidyl peptidase 3 
Protein Synonyms/Alias
 HCG2016942, isoform CRA_d 
Gene Name
 DPP3 
Gene Synonyms/Alias
 hCG_2016942 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
133YKSFGDTKFVPNLPKubiquitination[1]
140KFVPNLPKEKLERVIubiquitination[1]
185LRHLGLGKEGITTYFubiquitination[1]
222AYNTRLFKEVDGEGKubiquitination[1]
229KEVDGEGKPYYEVRLubiquitination[1]
255SEVTSKLKSYEFRGSubiquitination[1]
277DYAPILQKVVEQLEKubiquitination[1]
284KVVEQLEKAKAYAANubiquitination[1]
286VEQLEKAKAYAANSHubiquitination[1]
314QGSIEAHKRGSRFWIubiquitination[1]
357GFVAVVNKAMSAKFEubiquitination[1, 2]
362VNKAMSAKFERLVASubiquitination[1]
425LRQTEGFKNVSLGNVubiquitination[1, 3]
479LLGHGSGKLFVQDEKubiquitination[1]
486KLFVQDEKGAFNFDQubiquitination[2]
518SGETWDSKFSTIASSubiquitination[1, 4]
635SKIRSVGKPALERFLubiquitination[1, 3]
649LRRLQVLKSTGDVAGubiquitination[1, 2, 3, 4]
690LLRKESRKLIVQPNTubiquitination[1]
747TADARFWKGPSEAPSubiquitination[1, 2, 5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 757 AA 
Protein Sequence
MGEPEAGSEF ANGAAAAAGP MADTQYILPN DIGVSSLDCR EAFRLLSPTE RLYAYHLSRA 60
AWYGGLAVLL QTSPEAPYIY ALLSRLFRAQ DPDQLRQHAL AEGLTEEEYQ AFLVYAAGVY 120
SNMGNYKSFG DTKFVPNLPK EKLERVILGS EAAQQHPEEV RGLWQTCGEL MFSLEPRLRH 180
LGLGKEGITT YFSGNCTMED AKLAQDFLDS QNLSAYNTRL FKEVDGEGKP YYEVRLASVL 240
GSEPSLDSEV TSKLKSYEFR GSPFQVTRGD YAPILQKVVE QLEKAKAYAA NSHQGQMLAQ 300
YIESFTQGSI EAHKRGSRFW IQDKGPIVES YIGFIESYRD PFGSRGEFEG FVAVVNKAMS 360
AKFERLVASA EQLLKELPWP PTFEKDKFLT PDFTSLDVLT FAGSGIPAGI NIPNYDDLRQ 420
TEGFKNVSLG NVLAVAYATQ REKLTFLEED DKDLYILWKG PSFDVQVGLH ELLGHGSGKL 480
FVQDEKGAFN FDQETVINPE TGEQIQSWYR SGETWDSKFS TIASSYEECR AESVGLYLCL 540
HPQVLEIFGF EGADAEDVIY VNWLNMVRAG LLALEFYTPE AFNWRQAHMQ ARFVILRVLL 600
EAGEGLVTIT PTTGSDGRPD ARVRLDRSKI RSVGKPALER FLRRLQVLKS TGDVAGGRAL 660
YEGYATVTDA PPECFLTLRD TVLLRKESRK LIVQPNTRLE GSDVQLLEYE ASAAGLIRSF 720
SERFPEDGPE LEEILTQLAT ADARFWKGPS EAPSGQA 757 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0008239; F:dipeptidyl-peptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR005317; Dipeptidyl-peptase3. 
Pfam
  
SMART
  
PROSITE
  
PRINTS