UniProt Accession

 HACD3_HUMAN; Q9P035; A0PJA1; Q280Z3; Q6PD63; Q8IUI5; Q8NC86; Q8NCB1; Q96T12; Q9NQA7 

Genbank Protein ID

 AJ271091; AF161470; AK027421; AK074857; AK074898; BC019873; BC035508; BC047685; BC058912; DQ251107 

Genbank Nucleotide ID

 CAB69070.1; AAF29085.1; BAB55101.1; BAC11249.1; BAC11277.1; AAH19873.1; AAH35508.1; AAH47685.1; AAH58912.1; ABB83547.1 

Protein Name

 Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3 

Protein Synonyms/Alias

 3-hydroxyacyl-CoA dehydratase 3; HACD3; Butyrate-induced protein 1; B-ind1; hB-ind1; Protein tyrosine phosphatase-like protein PTPLAD1; Protein-tyrosine phosphatase-like A domain-containing protein 1 

Gene Name

 PTPLAD1 

Gene Synonyms/Alias

 BIND1; HACD3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
43	TENVLHFKAQGHGAK	ubiquitination	[1, 2, 3]
98	ERLTKQEKRPLFLAP	ubiquitination	[1, 3]
130	KEEERLNKLRLESEG	ubiquitination	[2]
319	FTLPYPVKIKVRFSF	ubiquitination	[1, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis. Involved in Rac1-signaling pathways leading to the modulation of gene expression. 

Sequence Annotation

 DOMAIN 5 94 CS.
 ACT_SITE 286 286 By similarity.
 ACT_SITE 293 293 By similarity.
 MOD_RES 114 114 Phosphoserine.  

Keyword

 Coiled coil; Complete proteome; Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Lyase; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 362 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005096; F:GTPase activator activity; TAS:ProtInc.
 GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
 GO:0007257; P:activation of JUN kinase activity; TAS:ProtInc.
 GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
 GO:0007249; P:I-kappaB kinase/NF-kappaB cascade; TAS:ProtInc.
 GO:0016601; P:Rac protein signal transduction; NAS:UniProtKB.
 GO:0007266; P:Rho protein signal transduction; IEA:Compara. 

Interpro

 IPR007052; CS-like_domain.
 IPR017447; CS_domain.
 IPR008978; HSP20-like_chaperone.
 IPR007482; Tyr_Pase-like_PTPLA. 

Pfam

 PF04969; CS
 PF04387; PTPLA 

SMART

  

PROSITE

 PS51203; CS 

PRINTS