CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043181
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 T-complex protein 1 subunit theta 
Protein Synonyms/Alias
  
Gene Name
 Cct8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
19TKGTVLIKTAEELMNacetylation[1]
19TKGTVLIKTAEELMNubiquitination[2]
29EELMNFSKGEENLMDubiquitination[2]
55NVIVTGGKVADIALHubiquitination[2]
77MLVRLNSKWDLRRLCacetylation[1, 3, 4]
85WDLRRLCKTVGATALacetylation[1, 5]
85WDLRRLCKTVGATALsuccinylation[5]
126VVVFKHEKEDGAISTacetylation[5]
126VVVFKHEKEDGAISTubiquitination[2]
159DDGVNTFKVLTRDKRacetylation[1, 3, 5]
159DDGVNTFKVLTRDKRsuccinylation[5]
159DDGVNTFKVLTRDKRubiquitination[2]
192YGEYAIKKFAEAFEAacetylation[1]
192YGEYAIKKFAEAFEAubiquitination[2]
211LAENSGVKANEVISKubiquitination[2]
218KANEVISKLYSVHQEacetylation[1]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Chaperone; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 239 AA 
Protein Sequence
XSCPFDGMIT ETKGTVLIKT AEELMNFSKG EENLMDAQVK AIAGTGANVI VTGGKVADIA 60
LHYANKYNIM LVRLNSKWDL RRLCKTVGAT ALPKLTPPVQ EEMGHCDSVY LSEVGDTQVV 120
VFKHEKEDGA ISTIVLRGST DNLMDDIERA VDDGVNTFKV LTRDKRLVPG GGATEIELAK 180
QITSYGEYAI KKFAEAFEAI PRALAENSGV KANEVISKLY SVHQEGNKNV GLDIEAEVP 239 
Gene Ontology
 GO:0044297; C:cell body; IDA:MGI.
 GO:0005832; C:chaperonin-containing T-complex; IDA:MGI.
 GO:0002199; C:zona pellucida receptor complex; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0007339; P:binding of sperm to zona pellucida; IDA:MGI.
 GO:0006457; P:protein folding; IEA:InterPro. 
Interpro
 IPR012721; Chap_CCT_theta.
 IPR002423; Cpn60/TCP-1.
 IPR027409; GroEL-like_apical_dom.
 IPR027413; GROEL-like_equatorial. 
Pfam
 PF00118; Cpn60_TCP1 
SMART
  
PROSITE
  
PRINTS