UniProt Accession

 H7BZL1_HUMAN; H7BZL1 

Genbank Protein ID

 AC009292; AC016355; AC103753 

Genbank Nucleotide ID

  

Protein Name

 Dual-specificity mitogen-activated protein kinase kinase 5 

Protein Synonyms/Alias

  

Gene Name

 MAP2K5 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
54	ERNIHGLKVNTRAGP	ubiquitination	[1]
79	SLPSNSLKKSSAELK	ubiquitination	[1]
87	KSSAELKKILANGQM	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 128 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005819; C:spindle; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:Compara.
 GO:0004672; F:protein kinase activity; IEA:Compara.
 GO:0000187; P:activation of MAPK activity; IEA:Compara.
 GO:0071363; P:cellular response to growth factor stimulus; IEA:Compara.
 GO:0070375; P:ERK5 cascade; IEA:Compara.
 GO:0007507; P:heart development; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; IEA:Compara.
 GO:2000342; P:negative regulation of chemokine (C-X-C motif) ligand 2 production; IEA:Compara.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IEA:Compara.
 GO:0045415; P:negative regulation of interleukin-8 biosynthetic process; IEA:Compara.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IEA:Compara.
 GO:0060761; P:negative regulation of response to cytokine stimulus; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0030307; P:positive regulation of cell growth; IEA:Compara.
 GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara. 

Interpro

 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS. 

Pfam

  

SMART

  

PROSITE

 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM 

PRINTS