UniProt Accession

 CR1L_MOUSE; Q64735; E9QL18; Q3TV30; Q58E68; Q61447; Q61449; Q8CF59; Q8K328 

Genbank Protein ID

 M34173; M34164; M34165; M34166; M34167; M34168; M34169; M34170; M34171; M34172; M34173; M34164; M34165; M34166; M34167; M34168; M34169; M34170; M34171; M34172; AK004825; AK160440; AC139206; BC028945; BC092048; M23529; M23446 

Genbank Nucleotide ID

 AAA37467.1; AAA37467.1; AAA37467.1; AAA37467.1; AAA37467.1; AAA37467.1; AAA37467.1; AAA37467.1; AAA37467.1; AAA37467.1; AAA37468.1; AAA37468.1; AAA37468.1; AAA37468.1; AAA37468.1; AAA37468.1; AAA37468.1; AAA37468.1; AAA37468.1; AAA37468.1; BAC25098.1; BAE35790.1; AAH28945.1; AAH92048.1; AAA37477.1; AAA37478.1 

Protein Name

 Complement component receptor 1-like protein 

Protein Synonyms/Alias

 Complement regulatory protein Crry; Protein p65 

Gene Name

 Cr1l 

Gene Synonyms/Alias

 Crry; Cry 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
353	QEMSGFQKGLGMKKE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Plays a crucial role in early embryonic development by maintaining fetomaternal tolerance. Also acts as a costimulatory factor for T-cells which favors IL-4 secretion. 

Sequence Annotation

 DOMAIN 83 143 Sushi 1.
 DOMAIN 144 205 Sushi 2.
 DOMAIN 206 276 Sushi 3.
 DOMAIN 278 338 Sushi 4.
 DOMAIN 340 400 Sushi 5.
 MOD_RES 460 460 Phosphoserine.
 MOD_RES 477 477 Phosphoserine.
 CARBOHYD 98 98 N-linked (GlcNAc...) (Potential).
 CARBOHYD 366 366 N-linked (GlcNAc...) (Potential).
 DISULFID 85 128 By similarity.
 DISULFID 115 141 By similarity.
 DISULFID 146 187 By similarity.
 DISULFID 173 203 By similarity.
 DISULFID 208 257 By similarity.
 DISULFID 237 274 By similarity.
 DISULFID 280 323 By similarity.
 DISULFID 309 336 By similarity.
 DISULFID 342 385 By similarity.
 DISULFID 371 398 By similarity.  

Keyword

 3D-structure; Alternative splicing; Complement pathway; Complete proteome; Developmental protein; Disulfide bond; Glycoprotein; Immunity; Innate immunity; Membrane; Phosphoprotein; Pregnancy; Receptor; Reference proteome; Repeat; Signal; Sushi; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 483 AA 

Protein Sequence

Gene Ontology

 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
 GO:0007565; P:female pregnancy; IEA:UniProtKB-KW.
 GO:0001701; P:in utero embryonic development; IGI:MGI.
 GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
 GO:0045916; P:negative regulation of complement activation; IMP:MGI. 

Interpro

 IPR000436; Sushi_SCR_CCP. 

Pfam

 PF00084; Sushi 

SMART

 SM00032; CCP 

PROSITE

 PS50923; SUSHI 

PRINTS