CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020197
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein misato homolog 1 
Protein Synonyms/Alias
  
Gene Name
 MSTO1 
Gene Synonyms/Alias
 LST005; SLTP005 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
39LGRATDSKEPPGELCubiquitination[1]
73RLILMDLKGSLSSLKubiquitination[1, 2]
80KGSLSSLKEEGGLYRubiquitination[1, 2]
89EGGLYRDKQLDAAIAubiquitination[1, 2, 3]
105QGKLTTHKEELYPKNubiquitination[1, 2]
140VKSIPNGKGSSPLPTubiquitination[1]
152LPTATTPKPLIPTEAubiquitination[1]
182RSICMIQKYNHDGEAubiquitination[1]
203GQGESVLKEPKYQEEubiquitination[1, 2, 4, 5]
206ESVLKEPKYQEELEDubiquitination[1, 2]
365DMLSFCGKKVVTAGAubiquitination[1, 6, 7]
366MLSFCGKKVVTAGAIubiquitination[1]
529ALARDLTKLDLRRWAubiquitination[1, 4, 5, 8]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [6] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [7] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [8] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Involved in the regulation of mitochondrial distribution and morphology. 
Sequence Annotation
 MOD_RES 495 495 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Membrane; Mitochondrion; Mitochondrion outer membrane; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 570 AA 
Protein Sequence
MAGGAREVLT LQLGHFAGFV GAHWWNQQDA ALGRATDSKE PPGELCPDVL YRTGRTLHGQ 60
ETYTPRLILM DLKGSLSSLK EEGGLYRDKQ LDAAIAWQGK LTTHKEELYP KNPYLQDFLS 120
AEGVLSSDGV WRVKSIPNGK GSSPLPTATT PKPLIPTEAS IRVWSDFLRV HLHPRSICMI 180
QKYNHDGEAG RLEAFGQGES VLKEPKYQEE LEDRLHFYVE ECDYLQGFQI LCDLHDGFSG 240
VGAKAAELLQ DEYSGRGIIT WGLLPGPYHR GEAQRNIYRL LNTAFGLVHL TAHSSLVCPL 300
SLGGSLGLRP EPPVSFPYLH YDATLPFHCS AILATALDTV TVPYRLCSSP VSMVHLADML 360
SFCGKKVVTA GAIIPFPLAP GQSLPDSLMQ FGGATPWTPL SACGEPSGTR CFAQSVVLRG 420
IDRACHTSQL TPGTPPPSAL HACTTGEEIL AQYLQQQQPG VMSSSHLLLT PCRVAPPYPH 480
LFSSCSPPGM VLDGSPKGAA VESIPVFGAL CSSSSLHQTL EALARDLTKL DLRRWASFMD 540
AGVEHDDVAE LLQELQSLAQ CYQGGDSLVD 570 
Gene Ontology
 GO:0005741; C:mitochondrial outer membrane; IDA:UniProtKB.
 GO:0043234; C:protein complex; IEA:InterPro.
 GO:0048311; P:mitochondrion distribution; IMP:UniProtKB.
 GO:0051258; P:protein polymerization; IEA:InterPro. 
Interpro
 IPR019605; Misato_II_myosin-like.
 IPR003008; Tubulin_FtsZ_GTPase. 
Pfam
 PF10644; Misat_Myo_SegII
 PF00091; Tubulin 
SMART
  
PROSITE
  
PRINTS