UniProt Accession

 ASGR2_RAT; P08290; Q5M8C9 

Genbank Protein ID

 M16347; J02762; X07636; BC088099 

Genbank Nucleotide ID

 AAA42038.1; AAA41522.1; CAA30476.1; AAH88099.1 

Protein Name

 Asialoglycoprotein receptor 2 

Protein Synonyms/Alias

 ASGP-R 2; ASGPR 2; Hepatic lectin R2/3; HL-2; rHL-2 

Gene Name

 Asgr2 

Gene Synonyms/Alias

 Asgr-2 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
135	EKKQKDIKADHSTLL	acetylation	[1]
146	STLLFHLKHFPLDLR	acetylation	[1]
219	EEQEFVVKHRGAFHI	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. 

Sequence Annotation

 DOMAIN 169 295 C-type lectin.
 MOD_RES 13 13 Phosphoserine (By similarity).
 LIPID 54 54 S-palmitoyl cysteine.
 CARBOHYD 97 97 N-linked (GlcNAc...).
 CARBOHYD 119 119 N-linked (GlcNAc...).
 CARBOHYD 165 165 N-linked (GlcNAc...).
 DISULFID 170 181 By similarity.
 DISULFID 198 293 By similarity.
 DISULFID 271 285 By similarity.  

Keyword

 Calcium; Complete proteome; Direct protein sequencing; Disulfide bond; Endocytosis; Glycoprotein; Lectin; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Receptor; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 301 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0030282; P:bone mineralization; IEP:RGD.
 GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
 GO:0009100; P:glycoprotein metabolic process; IEA:Compara.
 GO:0055088; P:lipid homeostasis; IEA:Compara.
 GO:0031647; P:regulation of protein stability; IEA:Compara. 

Interpro

 IPR001304; C-type_lectin.
 IPR016186; C-type_lectin-like.
 IPR018378; C-type_lectin_CS.
 IPR016187; C-type_lectin_fold.
 IPR005640; Lectin_N. 

Pfam

 PF00059; Lectin_C
 PF03954; Lectin_N 

SMART

 SM00034; CLECT 

PROSITE

 PS00615; C_TYPE_LECTIN_1
 PS50041; C_TYPE_LECTIN_2 

PRINTS