CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014708
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leucine-rich repeat-containing protein 8E 
Protein Synonyms/Alias
  
Gene Name
 Lrrc8e 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
231KKEGEQAKALFEKVKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 REPEAT 535 556 LRR 1.
 REPEAT 558 578 LRR 2.
 REPEAT 582 603 LRR 3.
 REPEAT 605 626 LRR 4.
 REPEAT 630 651 LRR 5.
 REPEAT 653 674 LRR 6.
 REPEAT 676 697 LRR 7.
 REPEAT 699 720 LRR 8.
 REPEAT 722 744 LRR 9.
 REPEAT 745 766 LRR 10.
 CARBOHYD 63 63 N-linked (GlcNAc...) (Potential).
 CARBOHYD 301 301 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Leucine-rich repeat; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 795 AA 
Protein Sequence
MIPVAEFKQF TEQQPAFKVL KPWWDVLAEY LTVAMLMIGV FGCTLQVTQD KIICLPSHES 60
RENISGAPCQ QLLPQGISEQ MGGLRELSGL KNNLDLQQYS FINQLCYETA LHWYAKYFPY 120
LVVIHTLIFM VCTSFWFKFP GTSSKIEHFI SILGKCFDSP WTTRALSEVS GENHKGPASG 180
RAMVTTVTTT GAGSGKVGEG EKEKVLIEPE KVVSEPPVVT LLDKKEGEQA KALFEKVKKF 240
RVHVEEGDIL YSMYIRQTVL KVCKFFAILV YNLIYVEKIS FLVACRVETS EITGYASFCC 300
NHTKAHLFSK LAFCYISFVC VYGITCLYTL YWLFHRPLKE YSFRSVREET GMNDIPDVKN 360
DFAFMLHLID QYDSLYSKRF AVFLSEVSES RLKQLNLNHE WTPEKLRQKL QRNMRGRLEL 420
SLCMLPGLPD TVFELSEVEA LRLEAICDIS FPPGLSQLVN LQELSLLHSP ARLPFSSQIF 480
LRDRLKVICV KFEELREVPL WVFGLRGLEE LHLEGLFPPE MARGATLESL RELKQLKVLS 540
LRSNAGKVPA SVTDVAGHLQ RLSLHNDGAR LLALNSLKKL AVLRELELVA CGLERIPHAI 600
FSLGALQELD LKDNHLRSIE EILSFQHCRK LVTLRLWHNQ IAYVPEHVRK LRSLEQLYLS 660
HNKLETLPTQ LGQCFGLRLL DLSHNGLRSL PPELGLLQSL QHLALSYNAL ESLPDELFFC 720
HKLRTLLLGY NHLTQLSPDV AALQALSRLE LKGNRLETLP EELGDCKGLK KSGLLVEDTL 780
YEGLPAEVRE KMEEE 795 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 
Interpro
 IPR001611; Leu-rich_rpt.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR021040; LRR_protein-8_N. 
Pfam
 PF12534; DUF3733 
SMART
 SM00369; LRR_TYP 
PROSITE
 PS51450; LRR 
PRINTS