CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010107
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 5'-3' exonuclease 
Protein Synonyms/Alias
  
Gene Name
 polA 
Gene Synonyms/Alias
 MPN_379; MP458 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
287GIKALAQKFSQL***acetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 5'-3' exonuclease acting preferentially on double- stranded DNA (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; DNA-binding; Exonuclease; Hydrolase; Nuclease; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 291 AA 
Protein Sequence
MKNAILIDGN SLAYRAYFAT WQQVEFAKLH NLPFNNAIRT MLMMCWNLLQ SKQYDYGVIS 60
FDTKAPTFRD QLYSEYKSKR SKTPSELLVQ IPVVKESLRH LGFLVCEQDG FEADDLIGSY 120
ARLMTQNNVA VDIYSSDRDL LQLVDSMTSV WLCVKGTKEM KEYNTDNFAE QFFGLTPKQV 180
IEYKGLVGDN SDNLTGIKGI GPKKGIDLLK QYGTIDNIFA NFDKLSKALQ TILQGQIDTA 240
KKFSFLASIK TDIKLNDDIV HAALKPIDKQ ALLELLDKYG IKALAQKFSQ L 291 
Gene Ontology
 GO:0008409; F:5'-3' exonuclease activity; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC. 
Interpro
 IPR020046; 5-3_exonucl_a-hlix_arch_N.
 IPR020045; 5-3_exonuclease_C.
 IPR002421; 5-3_exonuclease_N.
 IPR008918; HhH2. 
Pfam
 PF01367; 5_3_exonuc
 PF02739; 5_3_exonuc_N 
SMART
 SM00475; 53EXOc
 SM00279; HhH2 
PROSITE
  
PRINTS