UniProt Accession

 CACL1_HUMAN; Q86Y37; Q5XPL7; Q8IY11; Q8N7S4 

Genbank Protein ID

 AJ544771; AY743663; AK097728; AL139407; BC038294 

Genbank Nucleotide ID

 CAD67614.1; AAU89709.1; BAC05153.1; CAH73727.1; AAH38294.1 

Protein Name

 CDK2-associated and cullin domain-containing protein 1 

Protein Synonyms/Alias

 Cdk-associated cullin1 

Gene Name

 CACUL1 

Gene Synonyms/Alias

 C10orf46; CAC1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
102	DAAAAVAKAAPAPTA	ubiquitination	[1]
196	NHLERVSKELQASPP	ubiquitination	[1, 2]
239	NKFYIETKLNRDLKD	ubiquitination	[2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition. 

Sequence Annotation

  

Keyword

 Alternative splicing; Cell cycle; Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 369 AA 

Protein Sequence

Gene Ontology

 GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IMP:UniProtKB.
 GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.
 GO:0045860; P:positive regulation of protein kinase activity; IMP:UniProtKB.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 

Interpro

 IPR001373; Cullin_N.
 IPR016159; Cullin_repeat-like_dom. 

Pfam

 PF00888; Cullin 

SMART

  

PROSITE

 PS01256; CULLIN_1
 PS50069; CULLIN_2 

PRINTS