CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019609
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tribbles homolog 1 
Protein Synonyms/Alias
 TRB-1; G-protein-coupled receptor-induced gene 2 protein; GIG-2; SKIP1 
Gene Name
 TRIB1 
Gene Synonyms/Alias
 C8FW; GIG2; TRB1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
233LEDTHIMKGEDDALSubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity. 
Sequence Annotation
 DOMAIN 1 338 Protein kinase.  
Keyword
 Complete proteome; Polymorphism; Protein kinase inhibitor; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 372 AA 
Protein Sequence
MRVGPVRSAM SGASQPRGPA LLFPATRGVP AKRLLDADDA AAVAAKCPRL SECSSPPDYL 60
SPPGSPCSPQ PPPAAPGAGG GSGSAPGPSR IADYLLLPLA EREHVSRALC IHTGRELRCK 120
VFPIKHYQDK IRPYIQLPSH SNITGIVEVI LGETKAYVFF EKDFGDMHSY VRSRKRLREE 180
EAARLFKQIV SAVAHCHQSA IVLGDLKLRK FVFSTEERTQ LRLESLEDTH IMKGEDDALS 240
DKHGCPAYVS PEILNTTGTY SGKAADVWSL GVMLYTLLVG RYPFHDSDPS ALFSKIRRGQ 300
FCIPEHISPK ARCLIRSLLR REPSERLTAP EILLHPWFES VLEPGYIDSE IGTSDQIVPE 360
YQEDSDISSF FC 372 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:BHF-UCL.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0031434; F:mitogen-activated protein kinase kinase binding; IDA:BHF-UCL.
 GO:0004860; F:protein kinase inhibitor activity; IMP:BHF-UCL.
 GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
 GO:0031625; F:ubiquitin protein ligase binding; ISS:BHF-UCL.
 GO:0055106; F:ubiquitin-protein ligase regulator activity; ISS:BHF-UCL.
 GO:0007254; P:JNK cascade; IMP:BHF-UCL.
 GO:0031665; P:negative regulation of lipopolysaccharide-mediated signaling pathway; IMP:BHF-UCL.
 GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IMP:BHF-UCL.
 GO:0014912; P:negative regulation of smooth muscle cell migration; IMP:BHF-UCL.
 GO:0048662; P:negative regulation of smooth muscle cell proliferation; IMP:BHF-UCL.
 GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:BHF-UCL.
 GO:0043405; P:regulation of MAP kinase activity; IDA:UniProtKB.
 GO:0032496; P:response to lipopolysaccharide; IMP:BHF-UCL. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR024104; Tribbles/Ser_Thr_kinase_40.
 IPR024105; Tribbles_TRB1. 
Pfam
 PF00069; Pkinase 
SMART
  
PROSITE
 PS50011; PROTEIN_KINASE_DOM 
PRINTS