CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022289
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 UPF0609 protein C4orf27 
Protein Synonyms/Alias
  
Gene Name
 C4orf27 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
27TTDVKKSKFCEADVSubiquitination[1]
150VGINEAKKNCIIVPNubiquitination[1]
186KKKINLLKNIDEKLTacetylation[2]
186KKKINLLKNIDEKLTubiquitination[1]
220RDKKVVTKTFHGAGLubiquitination[1]
233GLVVPVDKNDVGYREacetylation[2]
233GLVVPVDKNDVGYREubiquitination[1, 3]
249PETDADLKRICKTIVubiquitination[1]
253ADLKRICKTIVEAASubiquitination[1, 3]
321PLAYNLLKRNLFAEIubiquitination[1, 4]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
 MOD_RES 186 186 N6-acetyllysine.
 MOD_RES 233 233 N6-acetyllysine.  
Keyword
 Acetylation; Complete proteome; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 346 AA 
Protein Sequence
MVGGGGKRRP GGEGPQCEKT TDVKKSKFCE ADVSSDLRKE VENHYKLSLP EDFYHFWKFC 60
EELDPEKPSD SLSASLGLQL VGPYDILAGK HKTKKKSTGL NFNLHWRFYY DPPEFQTIII 120
GDNKTQYHMG YFRDSPDEFP VYVGINEAKK NCIIVPNGDN VFAAVKLFLT KKLREITDKK 180
KINLLKNIDE KLTEAARELG YSLEQRTVKM KQRDKKVVTK TFHGAGLVVP VDKNDVGYRE 240
LPETDADLKR ICKTIVEAAS DEERLKAFAP IQEMMTFVQF ANDECDYGMG LELGMDLFCY 300
GSHYFHKVAG QLLPLAYNLL KRNLFAEIIE EHLANRSQEN IDQLAA 346 
Gene Ontology
 GO:0005634; C:nucleus; IDA:LIFEdb. 
Interpro
 IPR019361; DUF2228_C2H2_APLF-like. 
Pfam
 PF10228; DUF2228 
SMART
  
PROSITE
  
PRINTS