UniProt Accession

 SPCS1_MOUSE; Q9D958; Q8BJM2 

Genbank Protein ID

 BC034270; BC049895; AK007336; AK082928 

Genbank Nucleotide ID

 AAH49895.1; BAB24969.1; BAC38696.1 

Protein Name

 Signal peptidase complex subunit 1 

Protein Synonyms/Alias

 Microsomal signal peptidase 12 kDa subunit; SPase 12 kDa subunit 

Gene Name

 Spcs1 

Gene Synonyms/Alias

 Spc12 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
147	QDLGTEDKKSGDRKI	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Endoplasmic reticulum; Hydrolase; Membrane; Microsome; Protease; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 161 AA 

Protein Sequence

Gene Ontology

 GO:0030176; C:integral to endoplasmic reticulum membrane; ISS:UniProtKB.
 GO:0005787; C:signal peptidase complex; IEA:InterPro.
 GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
 GO:0043022; F:ribosome binding; IDA:MGI.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0006465; P:signal peptide processing; IEA:InterPro. 

Interpro

 IPR009542; SPC12. 

Pfam

 PF06645; SPC12 

SMART

  

PROSITE

  

PRINTS