UniProt Accession

 BAAT_HUMAN; Q14032; Q3B7W9; Q96L31 

Genbank Protein ID

 L34081; CR541918; AL359893; CH471105; BC009567; BC107424 

Genbank Nucleotide ID

 AAC37550.1; CAG46716.1; CAH72995.1; EAW58943.1; AAH09567.1; AAI07425.1 

Protein Name

 Bile acid-CoA:amino acid N-acyltransferase 

Protein Synonyms/Alias

 BACAT; BAT; Glycine N-choloyltransferase; Long-chain fatty-acyl-CoA hydrolase 

Gene Name

 BAAT 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
334	GDKTINSKAHAEQAI	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Involved in bile acid metabolism. In liver hepatocytes catalyzes the second step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi. The major components of bile are cholic acid and chenodeoxycholic acid. In a first step the bile acids are converted to an acyl-CoA thioester, either in peroxisomes (primary bile acids deriving from the cholesterol pathway), or cytoplasmic at the endoplasmic reticulum (secondary bile acids). May catalyze the conjugation of primary or secondary bile acids, or both. The conjugation increases the detergent properties of bile acids in the intestine, which facilitates lipid and fat-soluble vitamin absorption. In turn, bile acids are deconjugated by bacteria in the intestine and are recycled back to the liver for reconjugation (secondary bile acids). May also act as an acyl-CoA thioesterase that regulates intracellular levels of free fatty acids. In vitro, catalyzes the hydrolysis of long- and very long-chain saturated acyl-CoAs to the free fatty acid and coenzyme A (CoASH), and conjugates glycine to these acyl-CoAs. 

Sequence Annotation

 ACT_SITE 235 235 Charge relay system (Probable).
 ACT_SITE 328 328 Charge relay system (Probable).
 ACT_SITE 362 362 Charge relay system (Probable).  

Keyword

 Acyltransferase; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Fatty acid metabolism; Hydrolase; Lipid metabolism; Polymorphism; Reference proteome; Serine esterase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 418 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005782; C:peroxisomal matrix; TAS:Reactome.
 GO:0004091; F:carboxylesterase activity; IEA:UniProtKB-KW.
 GO:0047963; F:glycine N-choloyltransferase activity; IDA:UniProtKB.
 GO:0052815; F:medium-chain acyl-CoA hydrolase activity; IDA:UniProtKB.
 GO:0016410; F:N-acyltransferase activity; IDA:MGI.
 GO:0016290; F:palmitoyl-CoA hydrolase activity; IEA:EC.
 GO:0052817; F:very long chain acyl-CoA hydrolase activity; IDA:UniProtKB.
 GO:0006637; P:acyl-CoA metabolic process; IDA:UniProtKB.
 GO:0015721; P:bile acid and bile salt transport; TAS:Reactome.
 GO:0006699; P:bile acid biosynthetic process; IDA:UniProtKB.
 GO:0002152; P:bile acid conjugation; IDA:UniProtKB.
 GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
 GO:0006544; P:glycine metabolic process; IDA:UniProtKB.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0031100; P:organ regeneration; IEA:Compara.
 GO:0019530; P:taurine metabolic process; IDA:UniProtKB. 

Interpro

 IPR016662; Acyl-CoA_thioEstase_long-chain.
 IPR014940; BAAT_C.
 IPR006862; Thio_Ohase/aa_AcTrfase. 

Pfam

 PF08840; BAAT_C
 PF04775; Bile_Hydr_Trans 

SMART

  

PROSITE

  

PRINTS