| Tag | Content |
|---|
| CPLM ID | CPLM-016429 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ubiquitin-associated protein 1 |
Protein Synonyms/Alias | UBAP-1 |
Gene Name | Ubap1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 251 | EKMSLSSKVSLPPIP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (By similarity). |
Sequence Annotation | DOMAIN 17 63 UMA.
DOMAIN 389 430 UBA 1.
DOMAIN 451 498 UBA 2. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Endosome; Protein transport; Reference proteome; Repeat; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 502 AA |
Protein Sequence | MASKKLGTDV HGTFSYLDDV PFKIGDKFKT PAKVGLPIGF SLPDCLQVVR EMQYDFSLEK 60
KTIEWAEDIK LIQEAQREAE RKAEEAEAKV NSKSGPEGDS KVSFPKTHNT ATMPPPINPI 120
LASLQHNNIL TPTRVSSSAT KQKVLSPPHT KADFNPADFE CEEDPFDNLE LKTIDEKEEL 180
RNILVGTTGP IMAQLLDSNT ARGSSGAVLQ DEEVLASLEQ ATLDFKPLHK PNGFITLPQL 240
GNCEKMSLSS KVSLPPIPTV SNIKSLSFPK LDSDDSNQKT VKLASTFHST SCLRSGASRS 300
LLKPSTQSSA SELNGDHTLG LSALNLNSGT EVPTLTSSQM PSLSSVSVCT EESSPPDPCP 360
TVTPLNFSVS QVPNMPSCPQ AYLELQALSP SERQCVETVV NMGYSYDCVL RAMRKKGENI 420
EQILDYLFAH GQLCEKGFDP LLVEEALEMH QCSEEKMMEF LQLMSKFKEM GFELKDIKEV 480
LLLHNNDQDN ALEDLMARAG AS 502 |
Gene Ontology | GO:0005829; C:cytosol; ISS:UniProtKB. GO:0000813; C:ESCRT I complex; ISS:UniProtKB. GO:0043130; F:ubiquitin binding; ISS:UniProtKB. GO:0015031; P:protein transport; IEA:UniProtKB-KW. GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |