UniProt Accession

 E4PD_ECOLI; P0A9B6; P11603; Q2M9R5 

Genbank Protein ID

 X14436; U28377; U00096; AP009048 

Genbank Nucleotide ID

 CAA32603.1; AAA69094.1; AAC75964.1; BAE76991.1 

Protein Name

 D-erythrose-4-phosphate dehydrogenase 

Protein Synonyms/Alias

 E4PDH 

Gene Name

 epd 

Gene Synonyms/Alias

 gapB; b2927; JW2894 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
214	SIIPVDTKLAAGITR	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate. 

Sequence Annotation

 NP_BIND 12 13 NAD (By similarity).
 REGION 154 156 Substrate binding (Potential).
 REGION 213 214 Substrate binding (Potential).
 ACT_SITE 155 155 Nucleophile (By similarity).
 BINDING 81 81 NAD; via carbonyl oxygen (By similarity).
 BINDING 200 200 Substrate (Potential).
 BINDING 236 236 Substrate (Potential).
 BINDING 318 318 NAD (By similarity).  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; NAD; Oxidoreductase; Pyridoxine biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 339 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0048001; F:erythrose-4-phosphate dehydrogenase activity; IDA:EcoCyc.
 GO:0004365; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity; IDA:EcoCyc.
 GO:0051287; F:NAD binding; IDA:EcoCyc.
 GO:0006006; P:glucose metabolic process; IDA:EcoCyc.
 GO:0042823; P:pyridoxal phosphate biosynthetic process; IDA:EcoCyc.
 GO:0008615; P:pyridoxine biosynthetic process; IMP:EcoCyc. 

Interpro

 IPR006422; E4P_DH_bac.
 IPR020831; GlycerAld/Erythrose_P_DH.
 IPR020830; GlycerAld_3-P_DH_AS.
 IPR020829; GlycerAld_3-P_DH_cat.
 IPR020828; GlycerAld_3-P_DH_NAD(P)-bd.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF02800; Gp_dh_C
 PF00044; Gp_dh_N 

SMART

 SM00846; Gp_dh_N 

PROSITE

 PS00071; GAPDH 

PRINTS

 PR00078; G3PDHDRGNASE.