UniProt Accession

 EGFL7_HUMAN; Q9UHF1; B3KRP0; Q5M7Y5; Q5VUD5; Q96EG0 

Genbank Protein ID

 AF186111; AB125649; AL512735; AY358901; AY358902; AY358903; AK091964; AL590226; BC012377; BC088371 

Genbank Nucleotide ID

 AAF01429.1; BAD01469.1; CAC21666.1; AAQ89260.1; AAQ89261.1; AAQ89262.1; BAG52452.1; CAH71721.1; AAH12377.1; AAH88371.1 

Protein Name

 Epidermal growth factor-like protein 7 

Protein Synonyms/Alias

 EGF-like protein 7; Multiple epidermal growth factor-like domains protein 7; Multiple EGF-like domains protein 7; NOTCH4-like protein; Vascular endothelial statin; VE-statin; Zneu1 

Gene Name

 EGFL7 

Gene Synonyms/Alias

 MEGF7; UNQ187/PRO1449 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
93	YACCPGWKRTSGLPG	ubiquitination	[1, 2]
197	TGVDSAMKEEVQRLQ	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cells adhesion to the substrate in vitro (By similarity). 

Sequence Annotation

 DOMAIN 27 104 EMI.
 DOMAIN 103 135 EGF-like 1.
 DOMAIN 137 177 EGF-like 2; calcium-binding (Potential).
 DISULFID 31 89 By similarity.
 DISULFID 56 62 By similarity.
 DISULFID 88 102 By similarity.
 DISULFID 107 117 By similarity.
 DISULFID 111 123 By similarity.
 DISULFID 125 134 By similarity.
 DISULFID 141 152 By similarity.
 DISULFID 148 161 By similarity.
 DISULFID 163 176 By similarity.  

Keyword

 Angiogenesis; Calcium; Coiled coil; Complete proteome; Developmental protein; Differentiation; Disulfide bond; EGF-like domain; Polymorphism; Reference proteome; Repeat; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 273 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; ISS:UniProtKB.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
 GO:0030336; P:negative regulation of cell migration; IEA:Compara.
 GO:0001570; P:vasculogenesis; ISS:UniProtKB. 

Interpro

 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR018097; EGF_Ca-bd_CS.
 IPR013111; EGF_extracell.
 IPR011489; EMI_domain. 

Pfam

 PF07974; EGF_2
 PF07645; EGF_CA
 PF07546; EMI 

SMART

 SM00181; EGF
 SM00179; EGF_CA 

PROSITE

 PS00010; ASX_HYDROXYL
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA
 PS51041; EMI 

PRINTS