UniProt Accession

 ALKH_ECOLI; P0A955; P10177 

Genbank Protein ID

 X68871; M87458; L20897; X63694; U00096; AP009048 

Genbank Nucleotide ID

 CAA48732.1; AAA23723.1; AAA23862.1; CAA45222.1; AAC74920.1; BAA15658.1 

Protein Name

 KHG/KDPG aldolase 

Protein Synonyms/Alias

 4-hydroxy-2-oxoglutarate aldolase; 2-keto-4-hydroxyglutarate aldolase; KHG-aldolase; 2-dehydro-3-deoxy-phosphogluconate aldolase; 2-keto-3-deoxy-6-phosphogluconate aldolase; KDPG-aldolase; Phospho-2-dehydro-3-deoxygluconate aldolase; Phospho-2-keto-3-deoxygluconate aldolase 

Gene Name

 eda 

Gene Synonyms/Alias

 hga; kdgA; b1850; JW1839 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
5	***MKNWKTSAESIL	acetylation	[1]
24	VVPVIVVKKLEHAVP	acetylation	[1, 2]
25	VPVIVVKKLEHAVPM	acetylation	[1, 2]
34	EHAVPMAKALVAGGV	acetylation	[1]
133	DYGLKEFKFFPAEAN	acetylation	[1]
144	AEANGGVKALQAIAG	acetylation	[1]
202	GDYDRITKLAREAVE	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 

Functional Description

  

Sequence Annotation

 ACT_SITE 45 45
 ACT_SITE 49 49
 ACT_SITE 133 133 Schiff-base intermediate with KHG or  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Lyase; Multifunctional enzyme; Reference proteome; Schiff base. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 213 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0016020; C:membrane; IDA:UniProtKB.
 GO:0008675; F:2-dehydro-3-deoxy-phosphogluconate aldolase activity; IMP:EcoliWiki.
 GO:0008700; F:4-hydroxy-2-oxoglutarate aldolase activity; IEA:EC. 

Interpro

 IPR000887; Aldlse_KDPG_KHG.
 IPR013785; Aldolase_TIM. 

Pfam

 PF01081; Aldolase 

SMART

  

PROSITE

 PS00159; ALDOLASE_KDPG_KHG_1
 PS00160; ALDOLASE_KDPG_KHG_2 

PRINTS