UniProt Accession

 MAZ_HUMAN; P56270; A8QJL9; C6G496; G5E927; Q15703; Q8NFN7; Q99443 

Genbank Protein ID

 M94046; M93339; D85131; U33819; AB017335; AF489858; EF059746; FJ532357; AC009133; CH471238; CH471238 

Genbank Nucleotide ID

 BAA12728.1; AAB04121.1; BAA33064.1; AAN03800.1; ABN80996.1; ACS26236.1; EAW79996.1; EAW79997.1 

Protein Name

 Myc-associated zinc finger protein 

Protein Synonyms/Alias

 MAZI; Pur-1; Purine-binding transcription factor; Serum amyloid A-activating factor-1; SAF-1; Transcription factor Zif87; ZF87; Zinc finger protein 801 

Gene Name

 MAZ 

Gene Synonyms/Alias

 ZNF801 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
298	VYHLNRHKLSHSDEK	ubiquitination	[1]
378	CEAAFATKDRLRAHT	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter of the Sp1 family of transcription factors. Regulates inflammation-induced expression of serum amyloid A proteins. 

Sequence Annotation

 ZN_FING 190 212 C2H2-type 1.
 ZN_FING 279 301 C2H2-type 2.
 ZN_FING 307 329 C2H2-type 3.
 ZN_FING 337 360 C2H2-type 4.
 ZN_FING 366 388 C2H2-type 5.
 ZN_FING 392 413 C2H2-type 6; atypical.  

Keyword

 Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; RNA-binding; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 477 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IDA:UniProtKB.
 GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006369; P:termination of RNA polymerase II transcription; IDA:UniProtKB.
 GO:0006367; P:transcription initiation from RNA polymerase II promoter; IDA:UniProtKB. 

Interpro

 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

 PF00096; zf-C2H2 

SMART

 SM00355; ZnF_C2H2 

PROSITE

 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS