CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023522
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Coronin-1B 
Protein Synonyms/Alias
 Coronin-2 
Gene Name
 Coro1b 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
463RALRMLVKEQGERISubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity). 
Sequence Annotation
 REPEAT 80 120 WD 1.
 REPEAT 130 170 WD 2.
 REPEAT 174 213 WD 3.
 REPEAT 217 260 WD 4.
 REPEAT 265 305 WD 5.
 MOD_RES 2 2 Phosphoserine (By similarity).  
Keyword
 Actin-binding; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Phosphoprotein; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 484 AA 
Protein Sequence
MSFRKVVRQS KFRHVFGQPV KNDQCYEDIR VSRVTWDSTF CAVNPKFLAV IVEASGGGAF 60
MVLPLNKTGR IDKAYPTVCG HTGPVLDIDW CPHNDEVIAS GSEDCTVMVW QIPENGLTSP 120
LTEPVVVLEG HTKRVGIITW HPTARNVLLS AGCDNVVLIW NVGTAEELYR LDSLHPDLIY 180
NVSWNHNGSL FCSACKDKSV RIIDPRRGTL VAEREKAHEG ARPMRAIFLA DGKVFTTGFS 240
RMSERQLALW DPENLEEPMA LQELDSSNGA LLPFYDPDTS VVYVCGKGDS SIRYFEITDE 300
PPYIHFLNTF TSKEPQRGMG SMPKRGLEVS KCEIARFYKL HERKCEPIVM TVPRKSDLFQ 360
DDLYPDTAGP EAALEAEDWV SGQDANPILI SLREAYVPSK QRDLKVSRRN VLSDSRPASY 420
SRSGASTATA VTDVPSGNLA GAGEAGKLEE VMQELRALRM LVKEQGERIS RLEEQLGRME 480
NGDT 484 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IBA:RefGenome.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0051015; F:actin filament binding; IBA:RefGenome.
 GO:0030036; P:actin cytoskeleton organization; IBA:RefGenome. 
Interpro
 IPR027340; Coro1b.
 IPR015505; Coronin.
 IPR015048; DUF1899.
 IPR015049; DUF1900.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF08953; DUF1899
 PF08954; DUF1900
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS