UniProt Accession

 ILEUA_MOUSE; Q9D154; Q3TV23; Q5SUV7; Q9D0S8; Q9D7S8 

Genbank Protein ID

 AF426024; AF521697; AK003930; AK004500; AK008914; AK160167; AK160456; AL645808; BC011140; BC104333 

Genbank Nucleotide ID

 AAL57486.1; AAM95933.1; BAB23079.1; BAB23335.1; BAB25964.1; BAE35668.1; BAE35797.1; CAI25648.1; AAH11140.1; AAI04334.1 

Protein Name

 Leukocyte elastase inhibitor A 

Protein Synonyms/Alias

 Serine protease inhibitor EIA; Serpin B1a 

Gene Name

 Serpinb1a 

Gene Synonyms/Alias

 Serpinb1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
56	STAAQLSKTFHFDSV	acetylation	[1]
79	SLNAEVSKRGASHTL	acetylation	[1]
79	SLNAEVSKRGASHTL	ubiquitination	[2]
96	ANRLYGEKTYNFLPE	acetylation	[1]
248	TGLKKIEKQITLEKL	acetylation	[1, 3]
254	EKQITLEKLLEWTKR	acetylation	[1, 3]
260	EKLLEWTKRENLEFI	acetylation	[3]
277	HVKLPRFKIEESYTL	acetylation	[1]
277	HVKLPRFKIEESYTL	ubiquitination	[2]
301	QDLFSSSKADLSGMS	ubiquitination	[2]
317	SRDLFISKIVHKSFV	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

 Regulates the activity of the neutrophil proteases and thus, forms complexes with chymotrypsin, elastase, cathepsin G and proteinase-3. 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Protease inhibitor; Reference proteome; Serine protease inhibitor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 379 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005615; C:extracellular space; IBA:RefGenome.
 GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:RefGenome.
 GO:0042176; P:regulation of protein catabolic process; IPI:MGI.
 GO:0030162; P:regulation of proteolysis; IBA:RefGenome. 

Interpro

 IPR023795; Protease_inhib_I4_serpin_CS.
 IPR015557; Protease_inhib_serpin_B1.
 IPR023796; Serpin_dom.
 IPR000215; Serpin_fam. 

Pfam

 PF00079; Serpin 

SMART

 SM00093; SERPIN 

PROSITE

 PS00284; SERPIN 

PRINTS