CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012778
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Centrosome and spindle pole-associated protein 1 
Protein Synonyms/Alias
  
Gene Name
 CSPP1 
Gene Synonyms/Alias
 CSPP 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
673RTYNPWGKGGGGAPLubiquitination[1]
1017VHDFNELKDRDSETRubiquitination[2]
1066IKMQEGAKVDLDAIPubiquitination[1, 2]
1076LDAIPSAKVREQRMPubiquitination[1, 2, 3]
1136ERRRNKWKGLDIDSSubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 May play a role in cell-cycle-dependent microtubule organization. 
Sequence Annotation
 MOD_RES 527 527 Phosphoserine.
 MOD_RES 966 966 Phosphoserine.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1256 AA 
Protein Sequence
MLFPLQVAAV TSSVRDDPLE HCVSPRTRAR SPEICKMADN LDEFIEEQKA RLAEDKAELE 60
SDPPYMEMKG KLSAKLSENS KILISMAKEN IPPNSQQTRG SLGIDYGLSL PLGEDYERKK 120
HKLKEELRQD YRRYLTQGIT QGKRKKNFLS TSETDPSTLG VSLPIGERLS AKERLKLERN 180
KEYNQFLRGK EESSEKFRQV EKSTEPKSQR NKKPIGQVKP DLTSQIQTSC ENSEGPRKDV 240
LTPSEAYEEL LNQRRLEEDR YRQLDDEIEL RNRRIIKKAN EEVGISNLKH QRFASKAGIP 300
DRRFHRFNED RVFDRRYHRP DQDPEVSEEM DERFRYESDF DRRLSRVYTN DRMHRNKRGN 360
MPPMEHDGDV IEQSNIRISS AENKSAPDNE TSKSANQDTC SPFAGMLFGG EDRELIQRRK 420
EKYRLELLEQ MAEQQRNKRR EKDLELRVAA SGAQDPEKSP DRLKQFSVAP RHFEEMIPPE 480
RPRIAFQTPL PPLSAPSVPP IPSVHPVPSQ NEDLRSGLSS ALGEMVSPRI APLPPPPLLP 540
PLATNYRTPY DDAYYFYGSR NTFDPSLAYY GSGMMGVQPA AYVSAPVTHQ LAQPVVNTVG 600
QNELKITSDQ VINSGLIFED KPKPSKQSLQ SYQEALQQQI REREERRKKE REEKEEYEAK 660
LEAEMRTYNP WGKGGGGAPL RDAKGNLITD LNRMHRQNID AYHNPDARTY EDKRAVVSLD 720
PNLATSNAEN LEDAANKSSG HMQTQSSPFA RGNVFGEPPT ELQIKQQELY KNFLRFQIEE 780
KKQREEAERE RLRIAEEKEE RRLAEQRARI QQEYEEEQEK KREKEEEQRL KNEEHIRLAE 840
ERQKEAERKK KEEEEKYNLQ LQHYCERDNL IGEETKHMRQ PSPIVPALQN KIASKLQRPP 900
SVDSIIRSFI HESSMSRAQS PPVPARKNQL RAEEEKKNVI MELSEMRKQL RSEERRLQER 960
LLHMDSDDEI PIRKKERNPM DIFDMARHRL QAPVRRQSPK GLDAATFQNV HDFNELKDRD 1020
SETRVDLKFM YLDPPRDHHT LEIQQQALLR EQQKRLNRIK MQEGAKVDLD AIPSAKVREQ 1080
RMPRDDTSDF LKNSLLESDS AFIGAYGETY PAIEDDVLPP PSQLPSARER RRNKWKGLDI 1140
DSSRPNVAPD GLSLKSISSV NVDELRVRNE ERMRRLNEFH NKPINTDDES SLVDPDDIMK 1200
HIGDDGSNSV ATEPWLRPGT SETLKRFMAE QLNQEQQQIP GKPGTFTWQG LSTAHG 1256 
Gene Ontology
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0000922; C:spindle pole; IDA:UniProtKB.
 GO:0032467; P:positive regulation of cytokinesis; IMP:UniProtKB. 
Interpro
 IPR026708; CSPP1. 
Pfam
  
SMART
  
PROSITE
  
PRINTS