| Tag | Content |
|---|
| CPLM ID | CPLM-017605 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Neuropilin and tolloid-like protein 2 |
Protein Synonyms/Alias | Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2 |
Gene Name | NETO2 |
Gene Synonyms/Alias | BTCL2; UNQ1926/PRO4401 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 125 | IDRYCGVKSPPLIRS | ubiquitination | [1] | | 200 | VEQEEKTKPGQAVDC | ubiquitination | [1] | | 235 | MEHSNECKRNFVAVY | ubiquitination | [1] | | 254 | SIENLKAKFCSTVAN | ubiquitination | [1] | | 381 | RKKVMACKTAFNKTG | ubiquitination | [1] | | 386 | ACKTAFNKTGFQEVF | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity). |
Sequence Annotation | DOMAIN 45 159 CUB 1.
DOMAIN 177 292 CUB 2.
DOMAIN 296 332 LDL-receptor class A.
CARBOHYD 311 311 N-linked (GlcNAc...) (Potential).
DISULFID 45 72 By similarity.
DISULFID 100 122 By similarity.
DISULFID 177 207 By similarity.
DISULFID 234 256 By similarity.
DISULFID 297 309 By similarity.
DISULFID 304 322 By similarity.
DISULFID 316 331 By similarity. |
Keyword | Alternative splicing; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 525 AA |
Protein Sequence | MALERLCSVL KVLLITVLVV EGIAVAQKTQ DGQNIGIKHI PATQCGIWVR TSNGGHFASP 60
NYPDSYPPNK ECIYILEAAP RQRIELTFDE HYYIEPSFEC RFDHLEVRDG PFGFSPLIDR 120
YCGVKSPPLI RSTGRFMWIK FSSDEELEGL GFRAKYSFIP DPDFTYLGGI LNPIPDCQFE 180
LSGADGIVRS SQVEQEEKTK PGQAVDCIWT IKATPKAKIY LRFLDYQMEH SNECKRNFVA 240
VYDGSSSIEN LKAKFCSTVA NDVMLKTGIG VIRMWADEGS RLSRFRMLFT SFVEPPCTSS 300
TFFCHSNMCI NNSLVCNGVQ NCAYPWDENH CKEKKKAGVF EQITKTHGTI IGITSGIVLV 360
LLIISILVQV KQPRKKVMAC KTAFNKTGFQ EVFDPPHYEL FSLRDKEISA DLADLSEELD 420
NYQKMRRSST ASRCIHDHHC GSQASSVKQS RTNLSSMELP FRNDFAQPQP MKTFNSTFKK 480
SSYTFKQGHE CPEQALEDRV MEEIPCEIYV RGREDSAQAS ISIDF 525 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |