CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005718
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Kinesin heavy chain isoform 5C 
Protein Synonyms/Alias
 Kinesin heavy chain neuron-specific 2 
Gene Name
 Kif5c 
Gene Synonyms/Alias
 Nkhc2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
99KTHTMEGKLHDPQLMubiquitination[1]
445SQLAEKLKQQMLDQDubiquitination[1]
652YMQNMEQKRRQLEESubiquitination[1]
669SLSEELAKLRAQEKMubiquitination[1]
765EDQEREVKLEKLLLLubiquitination[1]
768EREVKLEKLLLLNDKubiquitination[1]
775KLLLLNDKREQAREDubiquitination[1]
832GSAAQKQKISFLENNubiquitination[1]
845NNLEQLTKVHKQLVRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Mediates dendritic trafficking of mRNAs. 
Sequence Annotation
 DOMAIN 2 386 Kinesin-motor.
 NP_BIND 86 93 ATP (By similarity).
 REGION 174 315 Microtubule-binding.
 REGION 859 956 Globular.
 MOD_RES 338 338 Phosphothreonine.
 MOD_RES 796 796 Phosphothreonine.  
Keyword
 3D-structure; ATP-binding; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Microtubule; Motor protein; Nucleotide-binding; Phosphoprotein; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 956 AA 
Protein Sequence
MADPAECSIK VMCRFRPLNE AEILRGDKFI PKFKGEETVV IGQGKPYVFD RVLPPNTTQE 60
QVYNACAKQI VKDVLEGYNG TIFAYGQTSS GKTHTMEGKL HDPQLMGIIP RIAHDIFDHI 120
YSMDENLEFH IKVSYFEIYL DKIRDLLDVS KTNLAVHEDK NRVPYVKGCT ERFVSSPEEV 180
MDVIDEGKAN RHVAVTNMNE HSSRSHSIFL INIKQENVET EKKLSGKLYL VDLAGSEKVS 240
KTGAEGAVLD EAKNINKSLS ALGNVISALA EGTKTHVPYR DSKMTRILQD SLGGNCRTTI 300
VICCSPSVFN EAETKSTLMF GQRAKTIKNT VSVNLELTAE EWKKKYEKEK EKNKALKSVL 360
QHLEMELNRW RNGEAVPEDE QISAKDQKSL EPCDNTPIID NITPVVDGIS AEKEKYDEEI 420
TSLYRQLDDK DDEINQQSQL AEKLKQQMLD QDELLASTRR DYEKIQEELT RLQIENEAAK 480
DEVKEVLQAL EELAVNYDQK SQEVEDKTRA NEQLTDELAQ KTTTLTTTQR ELSQLQELSN 540
HQKKRATEIL NLLLKDLGEI GGIIGTNDVK TLADVNGVIE EEFTMARLYI SKMKSEVKSL 600
VNRSKQLESA QMDSNRKMNA SERELAACQL LISQHEAKIK SLTDYMQNME QKRRQLEESQ 660
DSLSEELAKL RAQEKMHEVS FQDKEKEHLT RLQDAEEVKK ALEQQMESHR EAHQKQLSRL 720
RDEIEEKQRI IDEIRDLNQK LQLEQERLSS DYNKLKIEDQ EREVKLEKLL LLNDKREQAR 780
EDLKGLEETV SRELQTLHNL RKLFVQDLTT RVKKSVELDS DDGGGSAAQK QKISFLENNL 840
EQLTKVHKQL VRDNADLRCE LPKLEKRLRA TAERVKALES ALKEAKENAM RDRKRYQQEV 900
DRIKEAVRAK NMARRAHSAQ IAKPIRPGHY PASSPTAVHA VRGGGGGSSN STHYQK 956 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005875; C:microtubule associated complex; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003777; F:microtubule motor activity; IEA:InterPro.
 GO:0007018; P:microtubule-based movement; IEA:InterPro.
 GO:0051028; P:mRNA transport; IMP:UniProtKB. 
Interpro
 IPR019821; Kinesin_motor_CS.
 IPR001752; Kinesin_motor_dom.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00225; Kinesin 
SMART
 SM00129; KISc 
PROSITE
 PS00411; KINESIN_MOTOR_DOMAIN1
 PS50067; KINESIN_MOTOR_DOMAIN2 
PRINTS
 PR00380; KINESINHEAVY.