UniProt Accession

 TRPR_ECOLI; P0A881; P03032; Q2M5S4 

Genbank Protein ID

 J01715; L13768; U14003; U00096; AP009048; M69185 

Genbank Nucleotide ID

 AAA72140.1; AAA72134.1; AAA97289.1; AAC77346.1; BAE78382.1 

Protein Name

 Trp operon repressor 

Protein Synonyms/Alias

  

Gene Name

 trpR 

Gene Synonyms/Alias

 rtrY; b4393; JW4356 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
72	EMSQRELKNELGAGI	acetylation	[1]
106	WLEEVLLKSD*****	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region. 

Sequence Annotation

 DNA_BIND 68 91  

Keyword

 3D-structure; Complete proteome; Cytoplasm; DNA-binding; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 108 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0043565; F:sequence-specific DNA binding; IDA:EcoCyc.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:HAMAP.
 GO:0006355; P:regulation of transcription, DNA-dependent; IDA:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR000831; Trp_repress.
 IPR013335; Trp_repress_bac.
 IPR010921; Trp_repressor/repl_initiator. 

Pfam

 PF01371; Trp_repressor 

SMART

  

PROSITE

  

PRINTS