UniProt Accession

 D3Z148_MOUSE; D3Z148 

Genbank Protein ID

 AC023173 

Genbank Nucleotide ID

  

Protein Name

 Caveolin 

Protein Synonyms/Alias

  

Gene Name

 Cav1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
28	MADEVTEKQVYDAHT	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). 

Sequence Annotation

  

Keyword

 Cell membrane; Complete proteome; Golgi apparatus; Membrane; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 115 AA 

Protein Sequence

Gene Ontology

 GO:0002080; C:acrosomal membrane; IDA:MGI.
 GO:0005901; C:caveola; IDA:MGI.
 GO:0005938; C:cell cortex; IDA:MGI.
 GO:0005929; C:cilium; IDA:MGI.
 GO:0005783; C:endoplasmic reticulum; IDA:MGI.
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; IDA:MGI.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI.
 GO:0043234; C:protein complex; IPI:MGI.
 GO:0016504; F:peptidase activator activity; IMP:MGI.
 GO:0001525; P:angiogenesis; IGI:MGI.
 GO:0006816; P:calcium ion transport; IMP:MGI.
 GO:0070836; P:caveola assembly; IMP:MGI.
 GO:0006874; P:cellular calcium ion homeostasis; IMP:MGI.
 GO:0042632; P:cholesterol homeostasis; IMP:MGI.
 GO:0006897; P:endocytosis; TAS:MGI.
 GO:0000188; P:inactivation of MAPK activity; IMP:MGI.
 GO:0007595; P:lactation; IMP:MGI.
 GO:0019915; P:lipid storage; IMP:MGI.
 GO:0060056; P:mammary gland involution; IMP:MGI.
 GO:0000165; P:MAPK cascade; IMP:MGI.
 GO:0051899; P:membrane depolarization; IMP:MGI.
 GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IMP:MGI.
 GO:0001937; P:negative regulation of endothelial cell proliferation; IMP:MGI.
 GO:0030857; P:negative regulation of epithelial cell differentiation; IMP:MGI.
 GO:0045019; P:negative regulation of nitric oxide biosynthetic process; IMP:MGI.
 GO:0051001; P:negative regulation of nitric-oxide synthase activity; IMP:MGI.
 GO:0042524; P:negative regulation of tyrosine phosphorylation of Stat5 protein; IDA:MGI.
 GO:0033484; P:nitric oxide homeostasis; IMP:MGI.
 GO:0048554; P:positive regulation of metalloenzyme activity; IMP:MGI.
 GO:0045907; P:positive regulation of vasoconstriction; IMP:MGI.
 GO:0051260; P:protein homooligomerization; IDA:MGI.
 GO:0008104; P:protein localization; IMP:MGI.
 GO:0019217; P:regulation of fatty acid metabolic process; IMP:MGI.
 GO:0006940; P:regulation of smooth muscle contraction; IMP:MGI.
 GO:0003057; P:regulation of the force of heart contraction by chemical signal; IGI:MGI.
 GO:0043627; P:response to estrogen stimulus; IDA:MGI.
 GO:0001666; P:response to hypoxia; IMP:MGI.
 GO:0002931; P:response to ischemia; IMP:MGI.
 GO:0032570; P:response to progesterone stimulus; ISO:MGI.
 GO:0007519; P:skeletal muscle tissue development; IMP:MGI.
 GO:0006641; P:triglyceride metabolic process; IMP:MGI.
 GO:0001570; P:vasculogenesis; IMP:MGI.
 GO:0042310; P:vasoconstriction; IMP:MGI. 

Interpro

 IPR001612; Caveolin.
 IPR015504; Caveolin_1.
 IPR018361; Caveolin_CS. 

Pfam

 PF01146; Caveolin 

SMART

  

PROSITE

 PS01210; CAVEOLIN 

PRINTS