| Tag | Content |
|---|
| CPLM ID | CPLM-015633 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Filamin-binding LIM protein 1 |
Protein Synonyms/Alias | FBLP-1; CSX-associated LIM |
Gene Name | Fblim1 |
Gene Synonyms/Alias | Cal |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 190 | DVCGFCHKPVSPREL | acetylation | [1] | | 322 | RDGKDAFKIECMGRN | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin- containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity). |
Sequence Annotation | DOMAIN 183 244 LIM zinc-binding 1.
DOMAIN 245 302 LIM zinc-binding 2.
DOMAIN 303 372 LIM zinc-binding 3.
REGION 1 84 Intrinsically disordered (By similarity).
REGION 1 69 Filamin-binding (By similarity).
REGION 278 375 FERMT2-binding (By similarity). |
Keyword | Cell adhesion; Cell junction; Cell shape; Complete proteome; Cytoplasm; Cytoskeleton; LIM domain; Metal-binding; Reference proteome; Repeat; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 375 AA |
Protein Sequence | MASKPEKRVA SSVFITLAPP RRDVAVSEEV GQAACEARRA RPWEMLPTKT PGAAVGRSPK 60
TWTPSGKTNA SLSGVTPQLS NGGCSLPPPS LNEEDLDLPP PPPPPSAYLP LPEEEPPVLP 120
GKSLISDLEQ LHLPPPPPPP PPQAPSKGSS VHPPPGHAIP SEEELPPPPE EPVTLPEREV 180
STDVCGFCHK PVSPRELAVE AMKRQYHAQC FTCRTCRRQL AGQRFYQKDG RPLCEPCYQD 240
TLEKCGKCGE VVQEHVIRAL GKAFHPPCFT CVTCARCISD ESFALDSQNQ VYCVADFYRK 300
FAPVCSICEN PIIPRDGKDA FKIECMGRNF HENCYRCEDC SVLLSVEPTD QGCYPLNDHL 360
FCKPCHLKRS AAGCC 375 |
Gene Ontology | GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell. GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell. GO:0043231; C:intracellular membrane-bounded organelle; IEA:Compara. GO:0001725; C:stress fiber; ISS:UniProtKB. GO:0031005; F:filamin binding; ISS:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0016337; P:cell-cell adhesion; ISS:UniProtKB. GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW. GO:0033623; P:regulation of integrin activation; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |