CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015972
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tectonin beta-propeller repeat-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 TECPR1 
Gene Synonyms/Alias
 KIAA1358 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
370TPSELSGKTWKAIIAubiquitination[1]
373ELSGKTWKAIIAAREubiquitination[1]
580AQTAAWRKQIFQQLTubiquitination[2]
906YHGSKTMKDFVRRRCubiquitination[1]
1037SPPRQRLKQVSAGQTubiquitination[1]
1119GVQPHEPKGHGWDYGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. 
Sequence Annotation
 REPEAT 209 240 TECPR 1.
 REPEAT 254 285 TECPR 2.
 REPEAT 301 332 TECPR 3.
 REPEAT 344 376 TECPR 4.
 DOMAIN 611 717 PH.
 REPEAT 729 756 TECPR 5.
 REPEAT 953 984 TECPR 6.
 REPEAT 998 1029 TECPR 7.
 REPEAT 1044 1075 TECPR 8.
 REPEAT 1087 1127 TECPR 9.
 MOD_RES 938 938 Phosphoserine.
 MOD_RES 949 949 Phosphoserine.  
Keyword
 Alternative splicing; Autophagy; Complete proteome; Cytoplasmic vesicle; Lipid-binding; Lysosome; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1165 AA 
Protein Sequence
MPNSVLWAVD LFGRVYTLST AGQYWEMCKD SQLEFKRVSA TTQCCWGIAC DNQVYVYVCA 60
SDVPIRRREE AYENQRWNPM GGFCEKLLLS DRWGWSDVSG LQHRPLDRVA LPSPHWEWES 120
DWYVDENFGG EPTEKGGWTY AIDFPATYTK DKKWNSCVRR RKWIRYRRYK SRDIWAKIPS 180
KDDPKELPDP FNDLSVGGWE ITEEPVGRLS VWAVSLQGKV WYREDVSHSN PEGSSWSLLD 240
TPGEVVQISC GPHDLLWATL WEGQALVREG INRSNPKGSS WSIVEPPGSE NGVMHISVGV 300
SVVWAVTKDW KVWFRRGVNS HNPCGTSWIE MVGEMTMVNV GMNDQVWGIG CEDRAVYFRQ 360
GVTPSELSGK TWKAIIAARE CDRSHSGSSS SLLSAGCFFG DEVRGSGESA PSDTDASSEV 420
ERPGPGQILP AEPLDDSKNA TGNSASGLGA GRTAEDTVED ACPAEGSREA RPNTHPGPAP 480
TPAELPWTNI DLKEAKKVPS HSAAGFPETT SLSSLGLLPL GLEEPYGVDD HPLWAWVSGG 540
GCVVEACAMP RWFTVQAGLS SSVHMLSLSI TPAQTAAWRK QIFQQLTERT KRELENFRHY 600
EQAVEQSVWV KTGALQWWCD WKPHKWVDVR LALEQFTGHD GVRDSILFIY YVVHEEKKYI 660
HIFLNEVVAL VPVLNETKHS FALYTPERTR QRWPVRLAAA TEQDMNDWLA LLSLSCCESR 720
KVQGRPSPQA IWSITCKGDI FVSEPSPDLE AHEHPLPCDQ MFWRQMGGHL RMVEANSRGV 780
VWGIGYDHTA WVYTGGYGGG CFQGLASSTS NIYTQSDVKC VHIYENQRWN PVTGYTSRGL 840
PTDRYMWSDA SGLQECTKAG TKPPSLQWAW VSDWFVDFSV PGGTDQEGWQ YASDFPASYH 900
GSKTMKDFVR RRCWARKCKL VTSGPWLEVP PIALRDVSII PESPGAEGSG HSIALWAVSD 960
KGDVLCRLGV SELNPAGSSW LHVGTDQPFA SISIGACYQV WAVARDGSAF YRGSVYPSQP 1020
AGDCWYHIPS PPRQRLKQVS AGQTSVYALD ENGNLWYRQG ITPSYPQGSS WEHVSNNVCR 1080
VSVGPLDQVW VIANKVQGSH SLSRGTVCHR TGVQPHEPKG HGWDYGIGGG WDHISVRANA 1140
TRAPRSSSQE QEPSAPPEAH GPVCC 1165 
Gene Ontology
 GO:0000421; C:autophagic vacuole membrane; IDA:UniProtKB.
 GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
 GO:0032266; F:phosphatidylinositol-3-phosphate binding; IDA:UniProtKB.
 GO:0000046; P:autophagic vacuole fusion; IMP:UniProtKB. 
Interpro
 IPR006624; Beta-propeller_rpt_TECPR.
 IPR010482; Peroxin/Dysferlin.
 IPR006614; Peroxin/Ferlin.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF06462; Hyd_WA
 PF06398; Pex24p 
SMART
 SM00694; DysFC
 SM00693; DysFN
 SM00233; PH
 SM00706; TECPR 
PROSITE
 PS50003; PH_DOMAIN 
PRINTS