CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029080
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Oral-facial-digital syndrome 1 protein 
Protein Synonyms/Alias
  
Gene Name
 OFD1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
14LAEYHQAKESCNMETubiquitination[1]
35NRDSLAEKLQLIDDQubiquitination[1, 2, 3]
52DAYPQRIKFESLEIKubiquitination[1, 4]
116FEKACQAKSEALVLRubiquitination[1]
140KHQEIETKEIYAQRQubiquitination[1]
151AQRQLLLKDMDLLRGubiquitination[1]
252ELIAINSKKEELNQSubiquitination[1]
344PELAVFQKELRKAEKubiquitination[1, 2, 3]
351KELRKAEKAIVVEHEubiquitination[1]
393LGYKASVKSLTTQVAubiquitination[1, 2]
407ADLKLQLKQTQTALEubiquitination[1]
422NEVYCNPKQSVIDRSubiquitination[1]
455DFLNNPFKQENVLARubiquitination[1]
492LEFVANTKARVKELQubiquitination[1, 2, 3]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 872 AA 
Protein Sequence
MHFLKELAEY HQAKESCNME TQTSSTFNRD SLAEKLQLID DQFADAYPQR IKFESLEIKL 60
NEYKREIEEQ LRAEMCQKLK FFKDTEIAKI KMEAKKKYEK ELTMFQNDFE KACQAKSEAL 120
VLREKSTLER IHKHQEIETK EIYAQRQLLL KDMDLLRGRE AELKQRVEAF ELNQKLQEEK 180
HKSITEALRR QEQNIKSFEE TYDRKLKNEL LKYQLELKDD YIIRTNRLIE DERKNKEKAV 240
HLQEELIAIN SKKEELNQSV NRVKELELEL ESVKAQSLAI TKQNHMLNEK VKEMSDYSLL 300
KEEKLELLAQ NKLLKQQLEE SRNENLRLLN RLAQPAPELA VFQKELRKAE KAIVVEHEEF 360
ESCRQALHKQ LQDEIEHSAQ LKAQILGYKA SVKSLTTQVA DLKLQLKQTQ TALENEVYCN 420
PKQSVIDRSV NGLINGNVVP CNGEISGDFL NNPFKQENVL ARMVASRITN YPTAWVEGSS 480
PDSDLEFVAN TKARVKELQQ EAERLEKAFR SYHRRVIKNS AKSPLAAKSP PSLHLLEAFK 540
NITSSSPERH IFGEDRVVSE QPQVGTLEER NDVVEALTGS AASRLRGGTS SRRLSSTPLP 600
KAKRSLESEM YLEGLGRSHI ASPSPCPDRM PLPSPTESRH SLSIPPVSSP PEQKVGLYRR 660
QTELQDKSEF SDVDKLAFKD NEEFESSFES AGNMPRQLEM GGLSPAGDMS HVDAAAAAVP 720
LSYQHPSVDQ KQIEEQKEEE KIREQQVKER RQREERRQSN LQEVLERERR ELEKLYQERK 780
MIEESLKIKI KKELEMENEL EMSNQEIKDK SAHSENPLEK YMKIIQQEQD QESADKSSKK 840
MVQEGSLVDT LQSSDKVESL TGFSHEELDD SW 872 
Gene Ontology
 GO:0005814; C:centriole; IEA:Compara.
 GO:0005929; C:cilium; IEA:Compara.
 GO:0005932; C:microtubule basal body; IEA:Compara.
 GO:0015630; C:microtubule cytoskeleton; IDA:HPA.
 GO:0035083; P:cilium axoneme assembly; IEA:Compara.
 GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; IEA:Compara. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS